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Carbonyl reductase 1 catalyzes 20ß-reduction of glucocorticoids, modulating receptor activation and metabolic complications of obesity.
Morgan, Ruth A; Beck, Katharina R; Nixon, Mark; Homer, Natalie Z M; Crawford, Andrew A; Melchers, Diana; Houtman, René; Meijer, Onno C; Stomby, Andreas; Anderson, Anna J; Upreti, Rita; Stimson, Roland H; Olsson, Tommy; Michoel, Tom; Cohain, Ariella; Ruusalepp, Arno; Schadt, Eric E; Björkegren, Johan L M; Andrew, Ruth; Kenyon, Christopher J; Hadoke, Patrick W F; Odermatt, Alex; Keen, John A; Walker, Brian R.
Afiliação
  • Morgan RA; University/BHF Centre for Cardiovascular Science, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK. ruth.morgan@ed.ac.uk.
  • Beck KR; Royal (Dick) School of Veterinary Studies, University of Edinburgh, Edinburgh, UK. ruth.morgan@ed.ac.uk.
  • Nixon M; Division of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland.
  • Homer NZM; University/BHF Centre for Cardiovascular Science, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK.
  • Crawford AA; Mass Spectrometry Core Laboratory, Wellcome Trust Clinical Research Facility, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK.
  • Melchers D; University/BHF Centre for Cardiovascular Science, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK.
  • Houtman R; School of Social and Community Medicine, University of Bristol, Bristol, UK.
  • Meijer OC; PamGene International, Den Bosch, The Netherlands.
  • Stomby A; PamGene International, Den Bosch, The Netherlands.
  • Anderson AJ; Department of Internal Medicine, Division Endocrinology, Leiden University Medical Center, Leiden, The Netherlands.
  • Upreti R; Department of Public Health and Clinical Medicine, Umeå University, 901 87, Umeå, Sweden.
  • Stimson RH; University/BHF Centre for Cardiovascular Science, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK.
  • Olsson T; University/BHF Centre for Cardiovascular Science, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK.
  • Michoel T; University/BHF Centre for Cardiovascular Science, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK.
  • Cohain A; Department of Public Health and Clinical Medicine, Umeå University, 901 87, Umeå, Sweden.
  • Ruusalepp A; The Roslin Institute, University of Edinburgh, Easter Bush Campus, Edinburgh, UK.
  • Schadt EE; Department of Genetics and Genomic Sciences, Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, USA.
  • Björkegren JLM; Department of Physiology, Institute of Biomedicine and Translation Medicine, University of Tartu, Tartu, Estonia.
  • Andrew R; Clinical Gene Networks AB, Stockholm, Sweden.
  • Kenyon CJ; Department of Cardiac Surgery, Tartu University Hospital, Tartu, Estonia.
  • Hadoke PWF; Department of Genetics and Genomic Sciences, Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, USA.
  • Odermatt A; Department of Genetics and Genomic Sciences, Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, USA.
  • Keen JA; Department of Physiology, Institute of Biomedicine and Translation Medicine, University of Tartu, Tartu, Estonia.
  • Walker BR; Clinical Gene Networks AB, Stockholm, Sweden.
Sci Rep ; 7(1): 10633, 2017 09 06.
Article em En | MEDLINE | ID: mdl-28878267
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Receptores de Glucocorticoides / Metabolismo Energético / Carbonil Redutase (NADPH) / Glucocorticoides / Obesidade Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans / Male Idioma: En Ano de publicação: 2017 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Receptores de Glucocorticoides / Metabolismo Energético / Carbonil Redutase (NADPH) / Glucocorticoides / Obesidade Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans / Male Idioma: En Ano de publicação: 2017 Tipo de documento: Article