The mechanistic link between Arc/Arg3.1 expression and AMPA receptor endocytosis.
Semin Cell Dev Biol
; 77: 17-24, 2018 05.
Article
em En
| MEDLINE
| ID: mdl-28890421
ABSTRACT
The activity-regulated cytoskeleton associated protein (Arc/Arg3.1) plays a key role in determining synaptic strength through facilitation of AMPA receptor (AMPAR) endocytosis. Although there is considerable data on the mechanism by which Arc induction controls synaptic plasticity and learning behaviours, several key mechanistic questions remain. Here we review data on the link between Arc expression and the clathrin-mediated endocytic pathway which internalises AMPARs and discuss the significance of Arc binding to the clathrin adaptor protein 2 (AP-2) and to endophilin/dynamin. We consider which AMPAR subunits are selected for Arc-mediated internalisation, implications for synaptic function and consider Arc as a therapeutic target.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Receptores de AMPA
/
Proteínas do Citoesqueleto
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Endocitose
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Proteínas do Tecido Nervoso
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Plasticidade Neuronal
Limite:
Humans
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article