Primary afferent terminal excitability in the normal and spastic mutant mouse spinal cord.
Eur J Pharmacol
; 141(3): 371-82, 1987 Sep 23.
Article
em En
| MEDLINE
| ID: mdl-2889610
ABSTRACT
A microcomputer-based system has been used to apply the technique of excitability testing to the study of the actions of a range of pharmacological agents on the excitability of single primary afferent terminals in the mouse spinal cord in vitro. GABAA analogues all evoked increases in excitability that were bicuculline sensitive. GABA itself also evoked biphasic changes in excitability, or occasionally only suppressed terminal excitability. This latter effect was often enhanced in the presence of bicuculline, and resembled the action of the GABAB agonist, baclofen. The GABAA action could be enhanced by concurrent application of either benzodiazepine, midazolam or flurazepam. Bicuculline alone frequently decreased excitability. This action could be abolished by blocking synaptic activity with a low Ca2+ high Mg2+ superfusate, and was therefore considered to be due to reduction of the tonic action of GABA released at synaptic connections. Comparison of the action of these agents on terminals in the spastic mutant mouse showed an increased sensitivity of the GABA response to the benzodiazepines in mutant animals.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Medula Espinal
/
Espasticidade Muscular
/
Neurônios Aferentes
Limite:
Animals
Idioma:
En
Ano de publicação:
1987
Tipo de documento:
Article