The STIM-Orai Pathway: Orai, the Pore-Forming Subunit of the CRAC Channel.
Adv Exp Med Biol
; 993: 39-57, 2017.
Article
em En
| MEDLINE
| ID: mdl-28900908
ABSTRACT
This chapter focuses on the Orai proteins, Orai1-Orai3, with special emphasis on Orai1, in humans and other mammals, and on the definitive evidence that Orai is the pore subunit of the CRAC channel. It begins by reviewing briefly the defining characteristics of the CRAC channel, then discusses the studies that implicated Orai as part of the store-operated Ca2+ entry pathway and as the CRAC channel pore subunit, and finally examines ongoing work that is providing insights into CRAC channel structure and gating.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Moléculas de Interação Estromal
/
Canais de Cálcio Ativados pela Liberação de Cálcio
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article