Identification of transforming growth factor-beta-regulated microRNAs and the microRNA-targetomes in primary lung fibroblasts.

Ong, Jennie; Timens, Wim; Rajendran, Vijay; Algra, Arjan; Spira, Avrum; Lenburg, Marc E; Campbell, Joshua D; van den Berge, Maarten; Postma, Dirkje S; van den Berg, Anke; Kluiver, Joost; Brandsma, Corry-Anke

Ong, Jennie; Timens, Wim; Rajendran, Vijay; Algra, Arjan; Spira, Avrum; Lenburg, Marc E; Campbell, Joshua D; van den Berge, Maarten; Postma, Dirkje S; van den Berg, Anke; Kluiver, Joost; Brandsma, Corry-Anke.

Afiliação

Ong J; University of Groningen, University Medical Center Groningen, Department of Pathology and Medical Biology, Groningen, The Netherlands.
Timens W; University of Groningen, University Medical Center Groningen, Groningen Research Institute for Asthma and COPD (GRIAC), Groningen, The Netherlands.
Rajendran V; University of Groningen, University Medical Center Groningen, Department of Pathology and Medical Biology, Groningen, The Netherlands.
Algra A; University of Groningen, University Medical Center Groningen, Groningen Research Institute for Asthma and COPD (GRIAC), Groningen, The Netherlands.
Spira A; University of Groningen, University Medical Center Groningen, Department of Pathology and Medical Biology, Groningen, The Netherlands.
Lenburg ME; University of Groningen, University Medical Center Groningen, Groningen Research Institute for Asthma and COPD (GRIAC), Groningen, The Netherlands.
Campbell JD; University of Groningen, University Medical Center Groningen, Department of Pathology and Medical Biology, Groningen, The Netherlands.
van den Berge M; Boston University, School of Medicine, Department of Medicine, Section of Computational Biomedicine, Boston, Massachusetts, United States of America.
Postma DS; Boston University, School of Medicine, Department of Medicine, Section of Computational Biomedicine, Boston, Massachusetts, United States of America.
van den Berg A; Boston University, School of Medicine, Department of Medicine, Section of Computational Biomedicine, Boston, Massachusetts, United States of America.
Kluiver J; University of Groningen, University Medical Center Groningen, Groningen Research Institute for Asthma and COPD (GRIAC), Groningen, The Netherlands.
Brandsma CA; University of Groningen, University Medical Center Groningen, Department of Pulmonary Diseases, Groningen, The Netherlands.

PLoS One ; 12(9): e0183815, 2017.

Article em En | MEDLINE | ID: mdl-28910321

Assuntos

Proteínas Argonautas/metabolismo; Fibroblastos/efeitos dos fármacos; Pulmão/citologia; MicroRNAs/genética; Análise de Sequência com Séries de Oligonucleotídeos/métodos; Fator de Crescimento Transformador beta/farmacologia; Idoso; Células Cultivadas; Feminino; Fibroblastos/citologia; Fibroblastos/patologia; Perfilação da Expressão Gênica/métodos; Regulação da Expressão Gênica/efeitos dos fármacos; Redes Reguladoras de Genes; Humanos; Pulmão/patologia; Masculino; MicroRNAs/metabolismo; Pessoa de Meia-Idade; Doença Pulmonar Obstrutiva Crônica/genética; Doença Pulmonar Obstrutiva Crônica/patologia; Via de Sinalização Wnt/efeitos dos fármacos

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fator de Crescimento Transformador beta / Análise de Sequência com Séries de Oligonucleotídeos / MicroRNAs / Proteínas Argonautas / Fibroblastos / Pulmão Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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