Calcium-Induced Morphological Transitions in Peptide Amphiphiles Detected by 19F-Magnetic Resonance Imaging.
ACS Appl Mater Interfaces
; 9(46): 39890-39894, 2017 Nov 22.
Article
em En
| MEDLINE
| ID: mdl-28915004
ABSTRACT
Misregulation of extracellular Ca2+ can indicate bone-related pathologies. New, noninvasive tools are required to image Ca2+ fluxes and fluorine magnetic resonance imaging (19F-MRI) is uniquely suited to this challenge. Here, we present three, highly fluorinated peptide amphiphiles that self-assemble into nanoribbons in buffered saline and demonstrate these nanostructures can be programmed to change 19F-NMR signal intensity as a function of Ca2+ concentration. We determined these nanostructures show significant reduction in 19F-NMR signal as nanoribbon width increases in response to Ca2+, corresponding to 19F-MR image intensity reduction. Thus, these peptide amphiphiles can be used to quantitatively image biologically relevant Ca2+ concentrations.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Cálcio
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article