A thermodynamic analysis of the Collander equation and establishment of a reference solvent for use in drug partitioning studies.
J Pharm Pharmacol
; 39(10): 774-9, 1987 Oct.
Article
em En
| MEDLINE
| ID: mdl-2891814
ABSTRACT
A thermodynamic analysis of the Collander equation, ln PI = a + b ln PII (I and II refer to two different partitioning systems with partition coefficients PI and PII, respectively), is given and applied to three forms of correlation. The intercept, a, is shown to have no general fundamental significance whereas the slope, b is shown to reflect differences in non-aqueous solvent properties; b is also shown to be of use in scaling solvent behaviour to select solvents which closely represent biological membrane properties for use in partitioning studies. Laboratory and literature data are subjected to the analysis.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Preparações Farmacêuticas
Idioma:
En
Ano de publicação:
1987
Tipo de documento:
Article