Modulation of γ- and ß-Secretases as Early Prevention Against Alzheimer's Disease.
Biol Psychiatry
; 83(4): 320-327, 2018 02 15.
Article
em En
| MEDLINE
| ID: mdl-28918941
ABSTRACT
The genetic evidence implicating amyloid-ß in the initial stage of Alzheimer's disease is unequivocal. However, the long biochemical and cellular prodromal phases of the disease suggest that dementia is the result of a series of molecular and cellular cascades whose nature and connections remain unknown. Therefore, it is unlikely that treatments directed at amyloid-ß will have major clinical effects in the later stages of the disease. We discuss the two major candidate therapeutic targets to lower amyloid-ß in a preventive mode, i.e., γ- and ß-secretase; the rationale behind these two targets; and the current state of the field.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Peptídeos beta-Amiloides
/
Secretases da Proteína Precursora do Amiloide
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Doença de Alzheimer
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article