Structures of the Heme Acquisition Protein HasA with Iron(III)-5,15-Diphenylporphyrin and Derivatives Thereof as an Artificial Prosthetic Group.
Angew Chem Int Ed Engl
; 56(48): 15279-15283, 2017 11 27.
Article
em En
| MEDLINE
| ID: mdl-28921809
ABSTRACT
Iron(III)-5,15-diphenylporphyrin and several derivatives were accommodated by HasA, a heme acquisition protein secreted by Pseudomonas aeruginosa, despite possessing bulky substituents at the meso position of the porphyrin. Crystal structure analysis revealed that the two phenyl groups at the meso positions of porphyrin extend outside HasA. It was shown that the growth of P. aeruginosa was inhibited in the presence of HasA coordinating the synthetic porphyrins under iron-limiting conditions, and that the structure of the synthetic porphyrins greatly affects the inhibition efficiency.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Compostos Organometálicos
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Porfirinas
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Pseudomonas aeruginosa
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Proteínas de Bactérias
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Compostos Férricos
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Proteínas de Transporte
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article