Meropenem-induced Valproic Acid Elimination: A Case Report of Clinically Relevant Drug Interaction.
Prague Med Rep
; 118(2-3): 105-109, 2017.
Article
em En
| MEDLINE
| ID: mdl-28922108
ABSTRACT
We present two case reports of drug interaction between valproic acid and meropenem. In comparison with expected population-kinetic based serum levels, we observed 90.8 and 93.5% decrease in valproic acid serum levels during concomitant administration with meropenem. If carbapenems need to be administered to valproic acid treated patient, other anticonvulsant addition seems to be the appropriate as most probably the valproic acid dose escalation would not be sufficient to achieve therapeutic serum concentration.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tienamicinas
/
Ácido Valproico
/
Antibacterianos
/
Anticonvulsivantes
Limite:
Humans
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Male
/
Middle aged
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article