Computational design of environmental sensors for the potent opioid fentanyl.

Bick, Matthew J; Greisen, Per J; Morey, Kevin J; Antunes, Mauricio S; La, David; Sankaran, Banumathi; Reymond, Luc; Johnsson, Kai; Medford, June I; Baker, David

Bick, Matthew J; Greisen, Per J; Morey, Kevin J; Antunes, Mauricio S; La, David; Sankaran, Banumathi; Reymond, Luc; Johnsson, Kai; Medford, June I; Baker, David.

Afiliação

Bick MJ; Department of Biochemistry, University of Washington, Seattle, United States.
Greisen PJ; Department of Biochemistry, University of Washington, Seattle, United States.
Morey KJ; Department of Biology, Colorado State University, Fort Collins, United States.
Antunes MS; Department of Biology, Colorado State University, Fort Collins, United States.
La D; Department of Biochemistry, University of Washington, Seattle, United States.
Sankaran B; Molecular Biophysics and Integrated Bioimaging, Berkeley Center for Structural Biology, Lawrence Berkeley National Laboratory, Berkeley, United States.
Reymond L; Ecole Polytechnique Fédérale de Lausanne, Institute of Chemical Sciences and Engineering, Lausanne, Switzerland.
Johnsson K; Department of Chemical Biology, Max-Planck-Institute for Medical Research, Heidelberg, Germany.
Medford JI; Ecole Polytechnique Fédérale de Lausanne, Institute of Chemical Sciences and Engineering, Lausanne, Switzerland.
Baker D; Department of Chemical Biology, Max-Planck-Institute for Medical Research, Heidelberg, Germany.

Elife ; 62017 09 19.

Article em En | MEDLINE | ID: mdl-28925919

Assuntos

Biologia Computacional/métodos; Fentanila/metabolismo; Entorpecentes/metabolismo; Proteínas Recombinantes/genética; Proteínas Recombinantes/metabolismo; Cristalografia por Raios X; Expressão Gênica; Proteínas de Membrana/genética; Proteínas de Membrana/metabolismo; Ligação Proteica; Conformação Proteica; Proteínas Recombinantes/química; Saccharomyces cerevisiae/genética; Saccharomyces cerevisiae/metabolismo

Palavras-chave

A. thaliana; E. coli; S. cerevisiae; biochemistry; biosensors; computational biology; protein design; systems biology; transgenic plants

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Recombinantes / Fentanila / Biologia Computacional / Entorpecentes Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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