Selective HDL-Raising Human Apo A-I Gene Therapy Counteracts Cardiac Hypertrophy, Reduces Myocardial Fibrosis, and Improves Cardiac Function in Mice with Chronic Pressure Overload.

Amin, Ruhul; Muthuramu, Ilayaraja; Aboumsallem, Joseph Pierre; Mishra, Mudit; Jacobs, Frank; De Geest, Bart

Amin, Ruhul; Muthuramu, Ilayaraja; Aboumsallem, Joseph Pierre; Mishra, Mudit; Jacobs, Frank; De Geest, Bart.

Afiliação

Amin R; Centre for Molecular and Vascular Biology, Department of Cardiovascular Sciences, Catholic University of Leuven, 3000 Leuven, Belgium. mdruhul.amin@kuleuven.be.
Muthuramu I; Centre for Molecular and Vascular Biology, Department of Cardiovascular Sciences, Catholic University of Leuven, 3000 Leuven, Belgium. ilayaraja.muthuramu@kuleuven.be.
Aboumsallem JP; Centre for Molecular and Vascular Biology, Department of Cardiovascular Sciences, Catholic University of Leuven, 3000 Leuven, Belgium. josephpierre.aboumsallem@kuleuven.be.
Mishra M; Centre for Molecular and Vascular Biology, Department of Cardiovascular Sciences, Catholic University of Leuven, 3000 Leuven, Belgium. mudit.mishra@kuleuven.be.
Jacobs F; Centre for Molecular and Vascular Biology, Department of Cardiovascular Sciences, Catholic University of Leuven, 3000 Leuven, Belgium. FJACOBS1@its.jnj.com.
De Geest B; Centre for Molecular and Vascular Biology, Department of Cardiovascular Sciences, Catholic University of Leuven, 3000 Leuven, Belgium. bart.degeest@kuleuven.be.

Int J Mol Sci ; 18(9)2017 Sep 20.

Article em En | MEDLINE | ID: mdl-28930153

Assuntos

Apolipoproteína A-I/metabolismo; Cardiomegalia/terapia; Cardiomiopatias/terapia; Terapia Genética/métodos; Lipoproteínas HDL/metabolismo; Animais; Apolipoproteína A-I/genética; Cardiomegalia/genética; Cardiomegalia/metabolismo; Cardiomiopatias/genética; Cardiomiopatias/metabolismo; Fibrose/genética; Fibrose/terapia; Coração/fisiopatologia; Humanos; Estimativa de Kaplan-Meier; Masculino; Camundongos Endogâmicos C57BL; Camundongos Knockout; Miocárdio/metabolismo; Miocárdio/patologia

Palavras-chave

apolipoprotein A-I; cardiac function; cardiac hypertrophy; gene therapy; heart failure; high-density lipoproteins; oxidative stress; pressure overload

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Terapia Genética / Apolipoproteína A-I / Cardiomegalia / Lipoproteínas HDL / Cardiomiopatias Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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