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Precision medicine of frontotemporal dementia: from genotype to phenotype.
Che, Xiang-Qian; Song, Ning; Gao, Ying; Ren, Ru-Jing; Wang, Gang.
Afiliação
  • Che XQ; Department of Neurology and Neuroscience Institute, Ruijin Hospital affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
  • Song N; St Vincent's Hospital, Darlinghurst, Sydney NSW, Australia.
  • Gao Y; Department of Neurology and Neuroscience Institute, Ruijin Hospital affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
  • Ren RJ; Department of Neurology and Neuroscience Institute, Ruijin Hospital affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China, doctorren2001@126.com.
  • Wang G; Department of Neurology and Institute of Neuroscience, Ruijin Hospital affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 200025, China.
Front Biosci (Landmark Ed) ; 23(6): 1144-1165, 2018 01 01.
Article em En | MEDLINE | ID: mdl-28930593
Frontotemporal dementia (FTD) is the second most common neurodegenerative  cause of early-onset dementia. FTD has an important genetic component contributing to its pathogenic mechanisms. Currently, extensive research on neuroimaging biomarkers and neurochemical biomarkers in FTD is being conducted to address the clinical need for a sensitive and specific diagnostic marker. Here, we review the advances in genetics, biomarkers and treatment of FTD and how this may represent a shift towards precision medicine. To advance the clinical use of precision medicine, big data cohort for genotype/phenotype research and multidisciplinary team approaches are necessary.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Predisposição Genética para Doença / Demência Frontotemporal / Medicina de Precisão / Estudos de Associação Genética Limite: Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Predisposição Genética para Doença / Demência Frontotemporal / Medicina de Precisão / Estudos de Associação Genética Limite: Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article