Progress in understanding mucus abnormalities in cystic fibrosis airways.
J Cyst Fibros
; 17(2S): S35-S39, 2018 03.
Article
em En
| MEDLINE
| ID: mdl-28951068
ABSTRACT
Normal airways below the carina maintain an essentially sterile environment via a multi-pronged innate defence system that includes mucus clearance via mucociliary clearance and cough, multiple antimicrobials and cellular components including macrophages and neutrophils. In cystic fibrosis (CF), loss of CFTR function compromises these defences, and with present standard of care virtually all people with CF eventually develop mucus accumulation, plugging and chronic infections. This review focuses on how mucus is affected by CFTR loss.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Depuração Mucociliar
/
Regulador de Condutância Transmembrana em Fibrose Cística
/
Fibrose Cística
Limite:
Humans
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article