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Apolipoprotein E4 Impairs Neuronal Insulin Signaling by Trapping Insulin Receptor in the Endosomes.
Zhao, Na; Liu, Chia-Chen; Van Ingelgom, Alexandra J; Martens, Yuka A; Linares, Cynthia; Knight, Joshua A; Painter, Meghan M; Sullivan, Patrick M; Bu, Guojun.
Afiliação
  • Zhao N; Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.
  • Liu CC; Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA. Electronic address: liu.chiachen@mayo.edu.
  • Van Ingelgom AJ; Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.
  • Martens YA; Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.
  • Linares C; Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.
  • Knight JA; Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.
  • Painter MM; Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.
  • Sullivan PM; Departments of Medicine, Duke University School of Medicine, Durham, NC 27710, USA; GRECC, Durham Veterans Affairs Medical Center, Durham, NC 27705, USA.
  • Bu G; Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA; Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, College of Medicine, Xiamen University, Xiamen, Fujian, 361005, China. Electronic address: bu.guojun@mayo.edu.
Neuron ; 96(1): 115-129.e5, 2017 Sep 27.
Article em En | MEDLINE | ID: mdl-28957663
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Endossomos / Resistência à Insulina / Receptor de Insulina / Apolipoproteína E4 / Insulina / Neurônios Tipo de estudo: Risk_factors_studies Limite: Animals Idioma: En Ano de publicação: 2017 Tipo de documento: Article
Texto completo
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PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Endossomos / Resistência à Insulina / Receptor de Insulina / Apolipoproteína E4 / Insulina / Neurônios Tipo de estudo: Risk_factors_studies Limite: Animals Idioma: En Ano de publicação: 2017 Tipo de documento: Article