An efficient synthesis of deuterium-labeled degarelix acetate, a third-generation gonadotropin-releasing hormone receptor antagonist.
J Labelled Comp Radiopharm
; 61(4): 355-361, 2018 04.
Article
em En
| MEDLINE
| ID: mdl-28960413
ABSTRACT
Degarelix acetate, a third-generation gonadotropin-releasing hormone receptor antagonist, shows great potential in the treatment of many androgen-related diseases. To support clinical studies of degarelix acetate, deuterium-labeled degarelix is highly desired for use as an internal standard. Using D2 O/D3 PO4 as a deuterium source, 2-amino-3-(naphthalen-2-yl)propanoic acid was converted to deuterated degarelix acetate in 13 steps and in 14% overall yield.
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01-internacional
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MEDLINE
Assunto principal:
Oligopeptídeos
/
Receptores LHRH
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Deutério
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article