Tetherin Suppresses Type I Interferon Signaling by Targeting MAVS for NDP52-Mediated Selective Autophagic Degradation in Human Cells.

Jin, Shouheng; Tian, Shuo; Luo, Man; Xie, Weihong; Liu, Tao; Duan, Tianhao; Wu, Yaoxing; Cui, Jun

Jin, Shouheng; Tian, Shuo; Luo, Man; Xie, Weihong; Liu, Tao; Duan, Tianhao; Wu, Yaoxing; Cui, Jun.

Afiliação

Jin S; Key Laboratory of Gene Engineering of the Ministry of Education, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou, Guangdong 510275, China.
Tian S; Key Laboratory of Gene Engineering of the Ministry of Education, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou, Guangdong 510275, China.
Luo M; Key Laboratory of Gene Engineering of the Ministry of Education, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou, Guangdong 510275, China.
Xie W; Key Laboratory of Gene Engineering of the Ministry of Education, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou, Guangdong 510275, China.
Liu T; Key Laboratory of Gene Engineering of the Ministry of Education, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou, Guangdong 510275, China.
Duan T; Key Laboratory of Gene Engineering of the Ministry of Education, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou, Guangdong 510275, China.
Wu Y; Key Laboratory of Gene Engineering of the Ministry of Education, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou, Guangdong 510275, China.
Cui J; Key Laboratory of Gene Engineering of the Ministry of Education, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou, Guangdong 510275, China; Collaborative Innovation Center of Cancer Medicine, Sun Yat-sen University, Guangzhou, Guangdong 510006, China. El

Mol Cell ; 68(2): 308-322.e4, 2017 Oct 19.

Article em En | MEDLINE | ID: mdl-28965816

Assuntos

Proteínas Adaptadoras de Transdução de Sinal/metabolismo; Antígenos CD/metabolismo; Autofagia/fisiologia; Interferon Tipo I/metabolismo; Proteínas Nucleares/metabolismo; Transdução de Sinais/fisiologia; Células A549; Proteínas Adaptadoras de Transdução de Sinal/genética; Animais; Antígenos CD/genética; Proteína DEAD-box 58/genética; Proteína DEAD-box 58/metabolismo; Proteínas Ligadas por GPI/genética; Proteínas Ligadas por GPI/metabolismo; Células HeLa; Humanos; Interferon Tipo I/genética; Camundongos; Proteínas Nucleares/genética; Células RAW 264.7; Receptores Imunológicos; Ubiquitina/genética; Ubiquitina/metabolismo; Ubiquitina-Proteína Ligases/genética; Ubiquitina-Proteína Ligases/metabolismo; Ubiquitinação/fisiologia

Palavras-chave

K27-linked ubiquitination; MARCH8; MAVS; NDP52; Tetherin; selective autophagy; type I interferon

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Autofagia / Proteínas Nucleares / Transdução de Sinais / Interferon Tipo I / Antígenos CD / Proteínas Adaptadoras de Transdução de Sinal Limite: Animals / Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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