Development of a New FR-Targeting Agent <sup>99m</sup>Tc-HYNFA with Improved Imaging Contrast and Comparison of Multimerization and/or PEGylation Strategies for Radio-Folate Modification.

Guo, Zhide; You, Linyi; Shi, Changrong; Song, Manli; Gao, Mengna; Xu, Duo; Peng, Chenyu; Zhuang, Rongqiang; Liu, Ting; Su, Xinhui; Du, Jin; Zhang, Xianzhong

Development of a New FR-Targeting Agent ^99mTc-HYNFA with Improved Imaging Contrast and Comparison of Multimerization and/or PEGylation Strategies for Radio-Folate Modification.

Guo, Zhide; You, Linyi; Shi, Changrong; Song, Manli; Gao, Mengna; Xu, Duo; Peng, Chenyu; Zhuang, Rongqiang; Liu, Ting; Su, Xinhui; Du, Jin; Zhang, Xianzhong.

Afiliação

Guo Z; State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University , 4221-116 Xiang'An South Road, Xiamen 361102, China.
You L; Department of Isotope, China Institute of Atomic Energy , P.O. Box 2108, Beijing 102413, China.
Shi C; State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University , 4221-116 Xiang'An South Road, Xiamen 361102, China.
Song M; State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University , 4221-116 Xiang'An South Road, Xiamen 361102, China.
Gao M; State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University , 4221-116 Xiang'An South Road, Xiamen 361102, China.
Xu D; The First Affiliated Hospital of Zhengzhou University , Zhengzhou 450000, China.
Peng C; State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University , 4221-116 Xiang'An South Road, Xiamen 361102, China.
Zhuang R; State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University , 4221-116 Xiang'An South Road, Xiamen 361102, China.
Liu T; State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University , 4221-116 Xiang'An South Road, Xiamen 361102, China.
Su X; State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University , 4221-116 Xiang'An South Road, Xiamen 361102, China.
Du J; State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University , 4221-116 Xiang'An South Road, Xiamen 361102, China.
Zhang X; Zhongshan Hospital Affiliated of Xiamen University , Hubin South Road, Xiamen 361004, China.

Mol Pharm ; 14(11): 3780-3788, 2017 11 06.

Article em En | MEDLINE | ID: mdl-28969422

Assuntos

Ácido Fólico/química; Compostos de Organotecnécio/química; Tomografia Computadorizada de Emissão de Fóton Único/métodos; Animais; Receptores de Folato com Âncoras de GPI/química; Receptores de Folato com Âncoras de GPI/metabolismo; Humanos

Palavras-chave

99mTc labeling; PEGylation; SPECT/CT imaging; folate receptor; multimerization

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Compostos de Organotecnécio / Tomografia Computadorizada de Emissão de Fóton Único / Ácido Fólico Limite: Animals / Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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