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Exome-wide association study reveals novel psoriasis susceptibility locus at TNFSF15 and rare protective alleles in genes contributing to type I IFN signalling.
Dand, Nick; Mucha, Sören; Tsoi, Lam C; Mahil, Satveer K; Stuart, Philip E; Arnold, Andreas; Baurecht, Hansjörg; Burden, A David; Callis Duffin, Kristina; Chandran, Vinod; Curtis, Charles J; Das, Sayantan; Ellinghaus, David; Ellinghaus, Eva; Enerback, Charlotta; Esko, Tõnu; Gladman, Dafna D; Griffiths, Christopher E M; Gudjonsson, Johann E; Hoffman, Per; Homuth, Georg; Hüffmeier, Ulrike; Krueger, Gerald G; Laudes, Matthias; Lee, Sang Hyuck; Lieb, Wolfgang; Lim, Henry W; Löhr, Sabine; Mrowietz, Ulrich; Müller-Nurayid, Martina; Nöthen, Markus; Peters, Annette; Rahman, Proton; Reis, André; Reynolds, Nick J; Rodriguez, Elke; Schmidt, Carsten O; Spain, Sarah L; Strauch, Konstantin; Tejasvi, Trilokraj; Voorhees, John J; Warren, Richard B; Weichenthal, Michael; Weidinger, Stephan; Zawistowski, Matthew; Nair, Rajan P; Capon, Francesca; Smith, Catherine H; Trembath, Richard C; Abecasis, Goncalo R.
Afiliação
  • Dand N; Division of Genetics and Molecular Medicine, Faculty of Life Sciences & Medicine, King's College London, London, UK.
  • Mucha S; Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany.
  • Tsoi LC; Department of Dermatology.
  • Mahil SK; Department of Computational Medicine & Bioinformatics, University of Michigan Medical School, Ann Arbor, MI, USA.
  • Stuart PE; Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
  • Arnold A; St John's Institute of Dermatology, Faculty of Life Sciences & Medicine, King's College London, London, UK.
  • Baurecht H; Department of Dermatology.
  • Burden AD; Clinic and Polyclinic of Dermatology, University Medicine Greifswald, Greifswald, Germany.
  • Callis Duffin K; Department of Dermatology, Venereology and Allergy, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany.
  • Chandran V; Institute of Infection, Inflammation and Immunity, University of Glasgow, Glasgow, UK.
  • Curtis CJ; Department of Dermatology, University of Utah, Salt Lake City, UT, USA.
  • Das S; Department of Medicine.
  • Ellinghaus D; Department of Laboratory Medicine and Pathobiology.
  • Ellinghaus E; Institute of Medical Science, University of Toronto, Toronto, ON, Canada.
  • Enerback C; Krembil Research Institute, University Health Network, Toronto, ON, Canada.
  • Esko T; NIHR Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King's College London, London, UK.
  • Gladman DD; Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
  • Griffiths CEM; Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
  • Gudjonsson JE; Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany.
  • Hoffman P; Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany.
  • Homuth G; Division of Cell Biology and Dermatology, Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden.
  • Hüffmeier U; Estonian Biobank, Estonian Genome Center, University of Tartu, Tartu, Estonia.
  • Krueger GG; Department of Medicine.
  • Laudes M; Institute of Medical Science, University of Toronto, Toronto, ON, Canada.
  • Lee SH; Krembil Research Institute, University Health Network, Toronto, ON, Canada.
  • Lieb W; Dermatology Centre, Salford Royal Hospital, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK.
  • Lim HW; Department of Dermatology.
  • Löhr S; Genomics Research Group, Department of Biomedicine, University of Basel, Basel, Switzerland.
  • Mrowietz U; Institute of Human Genetics, University of Bonn, Bonn, Germany.
  • Müller-Nurayid M; Department of Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University Medicine and Ernst-Moritz-Arndt-University Greifswald, Greifswald, Germany.
  • Nöthen M; Institute of Human Genetics, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.
  • Peters A; Department of Dermatology, University of Utah, Salt Lake City, UT, USA.
  • Rahman P; I. Department of Medicine.
  • Reis A; NIHR Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King's College London, London, UK.
  • Reynolds NJ; Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
  • Rodriguez E; Institute of Epidemiology and Biobank PopGen, Christian-Albrechts-University of Kiel, Kiel, Germany.
  • Schmidt CO; Department of Dermatology, Henry Ford Hospital, Detroit, MI, USA.
  • Spain SL; Institute of Human Genetics, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.
  • Strauch K; Department of Dermatology, Venereology and Allergy, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany.
  • Tejasvi T; Institute of Genetic Epidemiology, Helmholtz Zentrum Munich, Neuherberg, Germany.
  • Voorhees JJ; Institute of Human Genetics, University of Bonn, Bonn, Germany.
  • Warren RB; Institute of Genetic Epidemiology, Helmholtz Zentrum Munich, Neuherberg, Germany.
  • Weichenthal M; Memorial University of Newfoundland, St. John's, NL, Canada.
  • Weidinger S; Institute of Human Genetics, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.
  • Zawistowski M; Dermatological Sciences, Institute of Cellular Medicine, Newcastle University Medical School, Newcastle upon Tyne, UK.
  • Nair RP; Department of Dermatology, Royal Victoria Infirmary, Newcastle Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK.
  • Capon F; Department of Dermatology, Venereology and Allergy, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany.
  • Smith CH; Institute for Community Medicine, Study of Health in Pomerania/KEF, University Medicine Greifswald, Greifswald, Germany.
  • Trembath RC; Division of Genetics and Molecular Medicine, Faculty of Life Sciences & Medicine, King's College London, London, UK.
  • Abecasis GR; Institute of Genetic Epidemiology, Helmholtz Zentrum Munich, Neuherberg, Germany.
Hum Mol Genet ; 26(21): 4301-4313, 2017 11 01.
Article em En | MEDLINE | ID: mdl-28973304
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Psoríase / Membro 15 da Superfamília de Ligantes de Fatores de Necrose Tumoral Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Limite: Female / Humans / Male Idioma: En Ano de publicação: 2017 Tipo de documento: Article
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Psoríase / Membro 15 da Superfamília de Ligantes de Fatores de Necrose Tumoral Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Limite: Female / Humans / Male Idioma: En Ano de publicação: 2017 Tipo de documento: Article