Recrudescing Plasmodium malariae infection despite appropriate treatment in an immigrant toddler.
Paediatr Int Child Health
; 38(4): 290-293, 2018 11.
Article
em En
| MEDLINE
| ID: mdl-28975859
ABSTRACT
Compared with other plasmodium species which cause human malaria, Plasmodium malariae is considered to be relatively infrequent and milder, although recent reports indicate that its prevalence and impact have been under-estimated. A 23-month-old boy, born and previously living in a refugee camp in Liberia who presented with P. malariae 6 weeks after arrival in the USA, is reported. Despite ostensibly effective anti-malarial treatment with artemether/lumefantrine and two courses of hydrochloroquine, he experienced recurrent parasitaemia, refractory anaemia and splenomegaly over a 6-month period; the symptoms resolved after he received atovaquone/proguanil. It is hypothesised that the recrudescing clinical malaria in this case was related to the long pre-erythrocytic phase unique to P. malariae, and potentially also to a proportion of the parasites being drug-resistant.
Palavras-chave
A/L: artemether/lumefantrine; AT-PG: atovaquone-proguanil; G6PD: glucose-6-phosphate dehydrogenase; HCQ: hydrochloroquine; LCM: left costal margin; MCV: mean corpuscular volume; Plasmodium malariae; RT-PCR: reverse transcriptase polymerase chain reaction; anaemia; malaria; refugee and immigrant health; splenomegaly
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Plasmodium malariae
/
Emigrantes e Imigrantes
/
Doenças Transmissíveis Importadas
/
Malária
/
Antimaláricos
Tipo de estudo:
Risk_factors_studies
Limite:
Humans
/
Infant
/
Male
País/Região como assunto:
Africa
/
America do norte
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article