Somatostatin-secreting islet cell tumor (somatostatinoma): suppression of growth hormone (GH) release induced by GH-releasing hormone.
J Clin Endocrinol Metab
; 67(1): 206-10, 1988 Jul.
Article
em En
| MEDLINE
| ID: mdl-2897973
ABSTRACT
A patient with a somatostatin (SRIH)-secreting islet cell tumor, whose only symptoms were dyspepsia and anemia, is described. The diagnosis of somatostatinoma was based on high plasma SRIH concentrations and immunocytochemical findings. The pancreatic exocrine response to secretin was decreased, whereas the insulin and/or glucagon responses to glucose and arginine were normal. Although the basal plasma GH concentration was normal, the plasma GH response to GHRH was subnormal. Gel permeation chromatography studies indicated that SRIH-14 was the predominant form of SRIH in plasma as well as in tumor tissue.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Pancreáticas
/
Somatostatinoma
/
Somatostatina
/
Hormônio do Crescimento
/
Hormônio Liberador de Hormônio do Crescimento
/
Adenoma de Células das Ilhotas Pancreáticas
Tipo de estudo:
Diagnostic_studies
Limite:
Aged
/
Female
/
Humans
Idioma:
En
Ano de publicação:
1988
Tipo de documento:
Article