Klotho protects the heart from hyperglycemia-induced injury by inactivating ROS and NF-&#954;B-mediated inflammation both in vitro and in vivo.

Guo, Yue; Zhuang, Xiaodong; Huang, Zena; Zou, Jing; Yang, Daya; Hu, Xun; Du, Zhimin; Wang, Lichun; Liao, Xinxue

Klotho protects the heart from hyperglycemia-induced injury by inactivating ROS and NF-κB-mediated inflammation both in vitro and in vivo.

Guo, Yue; Zhuang, Xiaodong; Huang, Zena; Zou, Jing; Yang, Daya; Hu, Xun; Du, Zhimin; Wang, Lichun; Liao, Xinxue.

Afiliação

Guo Y; Department of Cardiology, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510080, PR China; Key Laboratory of Assisted Circulation, Ministry of Health, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong 510080, PR China.
Zhuang X; Department of Cardiology, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510080, PR China.
Huang Z; Department of Critical Care Medicine and Emergency, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, PR China.
Zou J; Department of Neurology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong 510630, PR China.
Yang D; Department of Cardiology, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510080, PR China.
Hu X; Department of Cardiology, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510080, PR China.
Du Z; Department of Cardiology, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510080, PR China.
Wang L; Department of Cardiology, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510080, PR China; Key Laboratory of Assisted Circulation, Ministry of Health, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong 510080, PR China. Electronic address: wanglich@mail
Liao X; Department of Cardiology, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510080, PR China; Key Laboratory of Assisted Circulation, Ministry of Health, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong 510080, PR China. Electronic address: liaoxinx@mail

Biochim Biophys Acta Mol Basis Dis ; 1864(1): 238-251, 2018 Jan.

Article em En | MEDLINE | ID: mdl-28982613

Assuntos

Cardiotônicos/farmacologia; Cardiomiopatias Diabéticas/prevenção & controle; Glucose/efeitos adversos; Glucuronidase/farmacologia; Coração/efeitos dos fármacos; Miocardite/prevenção & controle; Miócitos Cardíacos/efeitos dos fármacos; Animais; Células Cultivadas; Citoproteção/efeitos dos fármacos; Diabetes Mellitus Experimental/complicações; Diabetes Mellitus Experimental/metabolismo; Diabetes Mellitus Experimental/patologia; Cardiomiopatias Diabéticas/metabolismo; Cardiomiopatias Diabéticas/patologia; Hiperglicemia/complicações; Hiperglicemia/imunologia; Hiperglicemia/metabolismo; Inflamação/metabolismo; Inflamação/patologia; Inflamação/prevenção & controle; Proteínas Klotho; Masculino; Camundongos; Camundongos Endogâmicos C57BL; Miocardite/metabolismo; Miocardite/patologia; Miócitos Cardíacos/fisiologia; NF-kappa B/metabolismo; Ratos; Espécies Reativas de Oxigênio/metabolismo

Palavras-chave

Diabetic complications; Inflammation; Klotho; Oxidative stress

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cardiotônicos / Miócitos Cardíacos / Cardiomiopatias Diabéticas / Glucose / Glucuronidase / Coração / Miocardite Limite: Animals Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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