NRF2 Is a Major Target of ARF in p53-Independent Tumor Suppression.

Chen, Delin; Tavana, Omid; Chu, Bo; Erber, Luke; Chen, Yue; Baer, Richard; Gu, Wei

Chen, Delin; Tavana, Omid; Chu, Bo; Erber, Luke; Chen, Yue; Baer, Richard; Gu, Wei.

Afiliação

Chen D; Institute for Cancer Genetics, Department of Pathology and Cell Biology, College of Physicians and Surgeons, Columbia University, 1130 St. Nicholas Avenue, New York, NY 10032, USA; Herbert Irving Comprehensive Cancer Center, College of Physicians and Surgeons, Columbia University, 1130 St. Nicholas
Tavana O; Institute for Cancer Genetics, Department of Pathology and Cell Biology, College of Physicians and Surgeons, Columbia University, 1130 St. Nicholas Avenue, New York, NY 10032, USA; Herbert Irving Comprehensive Cancer Center, College of Physicians and Surgeons, Columbia University, 1130 St. Nicholas
Chu B; Institute for Cancer Genetics, Department of Pathology and Cell Biology, College of Physicians and Surgeons, Columbia University, 1130 St. Nicholas Avenue, New York, NY 10032, USA; Herbert Irving Comprehensive Cancer Center, College of Physicians and Surgeons, Columbia University, 1130 St. Nicholas
Erber L; Departments of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA.
Chen Y; Departments of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA.
Baer R; Institute for Cancer Genetics, Department of Pathology and Cell Biology, College of Physicians and Surgeons, Columbia University, 1130 St. Nicholas Avenue, New York, NY 10032, USA; Herbert Irving Comprehensive Cancer Center, College of Physicians and Surgeons, Columbia University, 1130 St. Nicholas
Gu W; Institute for Cancer Genetics, Department of Pathology and Cell Biology, College of Physicians and Surgeons, Columbia University, 1130 St. Nicholas Avenue, New York, NY 10032, USA; Herbert Irving Comprehensive Cancer Center, College of Physicians and Surgeons, Columbia University, 1130 St. Nicholas

Mol Cell ; 68(1): 224-232.e4, 2017 Oct 05.

Article em En | MEDLINE | ID: mdl-28985506

Assuntos

Sistema y+ de Transporte de Aminoácidos/genética; Neoplasias Ósseas/genética; Inibidor de Quinase Dependente de Ciclina p18/genética; Regulação Neoplásica da Expressão Gênica; Fator 2 Relacionado a NF-E2/genética; Sistema y+ de Transporte de Aminoácidos/metabolismo; Animais; Neoplasias Ósseas/metabolismo; Neoplasias Ósseas/patologia; Linhagem Celular Tumoral; Inibidor p16 de Quinase Dependente de Ciclina; Inibidor de Quinase Dependente de Ciclina p18/metabolismo; Células Epiteliais/metabolismo; Células Epiteliais/patologia; Fibroblastos/citologia; Fibroblastos/metabolismo; Células HEK293; Xenoenxertos; Humanos; Camundongos; Camundongos Nus; Fator 2 Relacionado a NF-E2/metabolismo; Osteoblastos/metabolismo; Osteoblastos/patologia; Estresse Oxidativo; Espécies Reativas de Oxigênio/metabolismo; Transdução de Sinais; Proteína Supressora de Tumor p53/genética; Proteína Supressora de Tumor p53/metabolismo

Palavras-chave

ARF; NRF2; ROS; ferroptosis; oxidative stress; p53; transcriptional regulation

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Ósseas / Regulação Neoplásica da Expressão Gênica / Sistema y/ de Transporte de Aminoácidos / Inibidor de Quinase Dependente de Ciclina p18 / Fator 2 Relacionado a NF-E2 Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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