PAK4 crystal structures suggest unusual kinase conformational movements.

Zhang, Eric Y; Ha, Byung Hak; Boggon, Titus J

Zhang, Eric Y; Ha, Byung Hak; Boggon, Titus J.

Afiliação

Zhang EY; Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, 333 Cedar St., New Haven, CT 06520, United States.
Ha BH; Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, 333 Cedar St., New Haven, CT 06520, United States.
Boggon TJ; Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, 333 Cedar St., New Haven, CT 06520, United States; Department of Pharmacology, Yale University School of Medicine, 333 Cedar St., New Haven, CT 06520, United States. Electronic address: titus.boggon@yale.edu.

Biochim Biophys Acta Proteins Proteom ; 1866(2): 356-365, 2018 Feb.

Article em En | MEDLINE | ID: mdl-28993291

Assuntos

Quinases Ativadas por p21/química; Animais; Cristalografia por Raios X; Camundongos; Domínios Proteicos; Quinases Ativadas por p21/metabolismo

Palavras-chave

Back pocket; Crystal structure; Gatekeeper; Inhibitor design; Kinase conformation; Protein structure

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Quinases Ativadas por p21 Limite: Animals Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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