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Favipiravir and Ribavirin Treatment of Epidemiologically Linked Cases of Lassa Fever.
Raabe, Vanessa N; Kann, Gerrit; Ribner, Bruce S; Morales, Andres; Varkey, Jay B; Mehta, Aneesh K; Lyon, G Marshall; Vanairsdale, Sharon; Faber, Kelly; Becker, Stephan; Eickmann, Markus; Strecker, Thomas; Brown, Shelley; Patel, Ketan; De Leuw, Philipp; Schuettfort, Gundolf; Stephan, Christoph; Rabenau, Holger; Klena, John D; Rollin, Pierre E; McElroy, Anita; Ströher, Ute; Nichol, Stuart; Kraft, Colleen S; Wolf, Timo.
Afiliação
  • Raabe VN; Division of Infectious Diseases, Emory University, Atlanta, Georgia.
  • Kann G; Department of Medicine, Infectious Diseases Unit, Goethe University Hospital, Frankfurt/Main, Germany.
  • Ribner BS; Division of Infectious Diseases, Emory University, Atlanta, Georgia.
  • Morales A; Samaritan's Purse, Togo, West Africa.
  • Varkey JB; Division of Infectious Diseases, Emory University, Atlanta, Georgia.
  • Mehta AK; Division of Infectious Diseases, Emory University, Atlanta, Georgia.
  • Lyon GM; Division of Infectious Diseases, Emory University, Atlanta, Georgia.
  • Vanairsdale S; Emory Healthcare, Atlanta, Georgia.
  • Faber K; Hospital of Hope, Mango, Togo.
  • Becker S; Institute of Virology and Germany Centre for Infectious Diseases Research (DZIF), Gießen-Marburg-Langen, Philipps University, Marburg, Germany.
  • Eickmann M; Institute of Virology and Germany Centre for Infectious Diseases Research (DZIF), Gießen-Marburg-Langen, Philipps University, Marburg, Germany.
  • Strecker T; Institute of Virology and Germany Centre for Infectious Diseases Research (DZIF), Gießen-Marburg-Langen, Philipps University, Marburg, Germany.
  • Brown S; US Centers for Disease Control and Prevention, Viral Special Pathogens Branch, Atlanta, Georgia.
  • Patel K; US Centers for Disease Control and Prevention, Viral Special Pathogens Branch, Atlanta, Georgia.
  • De Leuw P; Department of Medicine, Infectious Diseases Unit, Goethe University Hospital, Frankfurt/Main, Germany.
  • Schuettfort G; Department of Medicine, Infectious Diseases Unit, Goethe University Hospital, Frankfurt/Main, Germany.
  • Stephan C; Department of Medicine, Infectious Diseases Unit, Goethe University Hospital, Frankfurt/Main, Germany.
  • Rabenau H; Institute of Medical Virology, University Hospital, Frankfurt, Germany.
  • Klena JD; US Centers for Disease Control and Prevention, Viral Special Pathogens Branch, Atlanta, Georgia.
  • Rollin PE; US Centers for Disease Control and Prevention, Viral Special Pathogens Branch, Atlanta, Georgia.
  • McElroy A; US Centers for Disease Control and Prevention, Viral Special Pathogens Branch, Atlanta, Georgia.
  • Ströher U; US Centers for Disease Control and Prevention, Viral Special Pathogens Branch, Atlanta, Georgia.
  • Nichol S; US Centers for Disease Control and Prevention, Viral Special Pathogens Branch, Atlanta, Georgia.
  • Kraft CS; Division of Infectious Diseases, Emory University, Atlanta, Georgia.
  • Wolf T; Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia.
Clin Infect Dis ; 65(5): 855-859, 2017 Sep 01.
Article em En | MEDLINE | ID: mdl-29017278
ABSTRACT
Two patients with Lassa fever are described who are the first human cases treated with a combination of ribavirin and favipiravir. Both patients survived but developed transaminitis and had prolonged detectable virus RNA in blood and semen, suggesting that the possibility of sexual transmission of Lassa virus should be considered.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Antivirais / Pirazinas / Ribavirina / Amidas / Febre Lassa Limite: Adult / Humans / Male País/Região como assunto: Africa Idioma: En Ano de publicação: 2017 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Antivirais / Pirazinas / Ribavirina / Amidas / Febre Lassa Limite: Adult / Humans / Male País/Região como assunto: Africa Idioma: En Ano de publicação: 2017 Tipo de documento: Article