Molecular modeling elucidates the cellular mechanism of synaptotagmin-SNARE inhibition: a novel plausible route to anti-wrinkle activity of botox-like cosmetic active molecules.

Wongrattanakamon, Pathomwat; Nimmanpipug, Piyarat; Sirithunyalug, Busaban; Jiranusornkul, Supat

Wongrattanakamon, Pathomwat; Nimmanpipug, Piyarat; Sirithunyalug, Busaban; Jiranusornkul, Supat.

Afiliação

Wongrattanakamon P; Laboratory for Molecular Design and Simulation (LMDS), Department of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University, Chiang Mai, 50200, Thailand. pathomwat@yahoo.com.
Nimmanpipug P; Computational Simulation and Modelling Laboratory (CSML), Department of Chemistry, Faculty of Science, Chiang Mai University, Chiang Mai, 50200, Thailand.
Sirithunyalug B; Department of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University, Chiang Mai, 50200, Thailand.
Jiranusornkul S; Laboratory for Molecular Design and Simulation (LMDS), Department of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University, Chiang Mai, 50200, Thailand. supat.jira@cmu.ac.th.

Mol Cell Biochem ; 442(1-2): 97-109, 2018 May.

Article em En | MEDLINE | ID: mdl-29019108

Assuntos

Simulação de Acoplamento Molecular; Peptídeos/química; Proteínas SNARE; Sinaptotagmina I/química; Humanos; Proteínas SNARE/antagonistas & inibidores; Proteínas SNARE/química

Palavras-chave

Anti-wrinkle; Botox-like peptides; Molecular docking; Molecular dynamics simulation; Neurotransmitters; SNARE proteins; Synaptotagmin

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Peptídeos / Sinaptotagmina I / Proteínas SNARE / Simulação de Acoplamento Molecular Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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