Expression of four types of human tyrosine hydroxylase in COS cells.
FEBS Lett
; 238(2): 431-4, 1988 Oct 10.
Article
em En
| MEDLINE
| ID: mdl-2901992
ABSTRACT
Alternative splicing from a single gene produces four kinds of human tyrosine hydroxylase (types 1-4), which have structural diversity only in the N-terminal region. We attempted expression of the type 1-4 enzymes in COS cells and performed kinetic analyses. All had enzymatic activities. The Km values of the four types for L-tyrosine and 6-methyl-5,6,7,8-tetrahydropteridine were similar, although their relative homospecific activities were clearly different. The type 1 enzyme displayed the highest activity.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tirosina 3-Mono-Oxigenase
/
Regulação da Expressão Gênica
Limite:
Humans
Idioma:
En
Ano de publicação:
1988
Tipo de documento:
Article