RNA-Seq Analysis of Differentiated Keratinocytes Reveals a Massive Response to Late Events during Human Papillomavirus 16 Infection, Including Loss of Epithelial Barrier Function.

Klymenko, T; Gu, Q; Herbert, I; Stevenson, A; Iliev, V; Watkins, G; Pollock, C; Bhatia, R; Cuschieri, K; Herzyk, P; Gatherer, D; Graham, S V

Klymenko, T; Gu, Q; Herbert, I; Stevenson, A; Iliev, V; Watkins, G; Pollock, C; Bhatia, R; Cuschieri, K; Herzyk, P; Gatherer, D; Graham, S V.

Afiliação

Klymenko T; MRC-University of Glasgow Centre for Virus Research, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom.
Gu Q; MRC-University of Glasgow Centre for Virus Research, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom.
Herbert I; MRC-University of Glasgow Centre for Virus Research, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom.
Stevenson A; MRC-University of Glasgow Centre for Virus Research, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom.
Iliev V; MRC-University of Glasgow Centre for Virus Research, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom.
Watkins G; MRC-University of Glasgow Centre for Virus Research, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom.
Pollock C; MRC-University of Glasgow Centre for Virus Research, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom.
Bhatia R; HPV Research Group, University of Edinburgh, Edinburgh, United Kingdom.
Cuschieri K; HPV Research Group, University of Edinburgh, Edinburgh, United Kingdom.
Herzyk P; Specialist Virology Centre, Royal Infirmary of Edinburgh, Edinburgh, United Kingdom.
Gatherer D; Institute of Molecular Cell and Systems Biology, Glasgow Polyomics, University of Glasgow, Glasgow, United Kingdom.
Graham SV; Division of Biomedical & Life Sciences, Faculty of Health & Medicine, Lancaster University, Lancaster, United Kingdom.

J Virol ; 91(24)2017 12 15.

Article em En | MEDLINE | ID: mdl-29021401

Assuntos

Papillomavirus Humano 16/patogenicidade; Queratinócitos/citologia; Infecções por Papillomavirus/genética; Análise de Sequência de RNA/métodos; Displasia do Colo do Útero/virologia; Neoplasias do Colo do Útero/virologia; Células 3T3; Animais; Diferenciação Celular; Linhagem Celular; Feminino; Regulação da Expressão Gênica; Redes Reguladoras de Genes; Sequenciamento de Nucleotídeos em Larga Escala/métodos; Papillomavirus Humano 16/fisiologia; Humanos; Queratinócitos/efeitos dos fármacos; Queratinócitos/virologia; Camundongos; Neoplasias do Colo do Útero/genética; Replicação Viral; Displasia do Colo do Útero/genética

Palavras-chave

cervical disease; epithelial cells; epithelial differentiation; human papillomavirus 16; keratinocyte transcriptome

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Queratinócitos / Displasia do Colo do Útero / Neoplasias do Colo do Útero / Análise de Sequência de RNA / Infecções por Papillomavirus / Papillomavirus Humano 16 Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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