Reverse Translational Research of ABCG2 (BCRP) in Human Disease and Drug Response.
Clin Pharmacol Ther
; 103(2): 233-242, 2018 02.
Article
em En
| MEDLINE
| ID: mdl-29023674
ABSTRACT
Reverse translational research takes a bedside-to-bench approach, using sophisticated basic research to explain the biological mechanisms behind observed clinical data. For transporters, which play a role in human disease and drug response, this approach offers a distinct advantage over the typical translational research, which often falters due to inadequate in vitro and preclinical animal models. Research on ABCG2, which encodes the Breast Cancer Resistance Protein, has benefited immensely from a reverse translational approach due to its broad implications for disease susceptibility and both therapeutic and adverse drug response. In this review, we describe the success of reverse translational research for ABCG2 and opportunities for further studies.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Medicina Baseada em Evidências
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Descoberta de Drogas
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Pesquisa Translacional Biomédica
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Membro 2 da Subfamília G de Transportadores de Cassetes de Ligação de ATP
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Desenvolvimento de Medicamentos
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Proteínas de Neoplasias
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Neoplasias
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Antineoplásicos
Tipo de estudo:
Etiology_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Animals
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Humans
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article