A Lewis Base Catalysis Approach for the Photoredox Activation of Boronic Acids and Esters.
Angew Chem Int Ed Engl
; 56(47): 15136-15140, 2017 11 20.
Article
em En
| MEDLINE
| ID: mdl-29024307
ABSTRACT
We report herein the use of a dual catalytic system comprising a Lewis base catalyst such as quinuclidin-3-ol or 4-dimethylaminopyridine and a photoredox catalyst to generate carbon radicals from either boronic acids or esters. This system enabled a wide range of alkyl boronic esters and aryl or alkyl boronic acids to react with electron-deficient olefins via radical addition to efficiently form C-C coupled products in a redox-neutral fashion. The Lewis base catalyst was shown to form a redox-active complex with either the boronic esters or the trimeric form of the boronic acids (boroxines) in solution.
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01-internacional
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MEDLINE
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En
Ano de publicação:
2017
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Article