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Legacy data sharing to improve drug safety assessment: the eTOX project.
Sanz, Ferran; Pognan, François; Steger-Hartmann, Thomas; Díaz, Carlos; Cases, Montserrat; Pastor, Manuel; Marc, Philippe; Wichard, Joerg; Briggs, Katharine; Watson, David K; Kleinöder, Thomas; Yang, Chihae; Amberg, Alexander; Beaumont, Maria; Brookes, Anthony J; Brunak, Søren; Cronin, Mark T D; Ecker, Gerhard F; Escher, Sylvia; Greene, Nigel; Guzmán, Antonio; Hersey, Anne; Jacques, Pascale; Lammens, Lieve; Mestres, Jordi; Muster, Wolfgang; Northeved, Helle; Pinches, Marc; Saiz, Javier; Sajot, Nicolas; Valencia, Alfonso; van der Lei, Johan; Vermeulen, Nico P E; Vock, Esther; Wolber, Gerhard; Zamora, Ismael.
Afiliação
  • Sanz F; Institut Hospital del Mar d'Investigacions Mèdiques (IMIM), Universitat Pompeu Fabra, 08003 Barcelona, Spain.
  • Pognan F; Novartis Institute for Biomedical Research, Basel, CH-4002, Switzerland.
  • Steger-Hartmann T; Bayer AG, 13353 Berlin, Germany.
  • Díaz C; Synapse Research Management Partners, 08007 Barcelona, Spain.
  • Cases M; Synapse Research Management Partners, 08007 Barcelona, Spain.
  • Pastor M; Institut Hospital del Mar d'Investigacions Mèdiques (IMIM), Universitat Pompeu Fabra, 08003 Barcelona, Spain.
  • Marc P; Novartis Institute for Biomedical Research, Basel, CH-4002, Switzerland.
  • Wichard J; Bayer AG, 13353 Berlin, Germany.
  • Briggs K; Lhasa Ltd, Leeds LS11 5PS, UK.
  • Watson DK; Lhasa Ltd, Leeds LS11 5PS, UK.
  • Kleinöder T; Molecular Networks GmbH, 90411 Nürnberg, Germany.
  • Yang C; Molecular Networks GmbH, 90411 Nürnberg, Germany.
  • Amberg A; Sanofi, 65926 Frankfurt am Main, Germany.
  • Beaumont M; GlaxoSmithKline Research and Development Ltd, Stevenage SG1 2NY, UK.
  • Brookes AJ; University of Leicester, Leicester LE1 7RH, UK.
  • Brunak S; Technical University of Denmark (DTU), 2800 Lyngby, Denmark.
  • Cronin MTD; Liverpool John Moores University, Liverpool L3 3AF, UK.
  • Ecker GF; Universität Wien, 1090 Vienna, Austria.
  • Escher S; Fraunhofer Institute for Toxicology and Experimental Medicine (ITEM), 30625 Hannover, Germany.
  • Greene N; Pfizer Ltd, Groton, Connecticut 06340, USA. Current affiliation: AstraZeneca, Waltham, Massachusettts 02451, USA.
  • Guzmán A; ESTEVE, 08041 Barcelona, Spain.
  • Hersey A; European Bioinformatics Institute, European Molecular Biology Laboratory, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
  • Jacques P; UCB Pharma SA, 1070 Brussels, Belgium.
  • Lammens L; Janssen Pharmaceutica NV, 2340 Beerse, Belgium.
  • Mestres J; Chemotargets SL, 08003 Barcelona, Spain.
  • Muster W; F. Hoffmann-La Roche AG, CH-4070 Basel, Switzerland.
  • Northeved H; H. Lundbeck A/S, 2500 Copenhagen, Denmark.
  • Pinches M; AstraZeneca AB, SK10 2NA Cheshire, UK. Current affiliation: Lhasa Ltd, Leeds LS11 5PS, UK.
  • Saiz J; Universitat Politècnica de València, 46022 València, Spain.
  • Sajot N; Servier, 45000 Orléans, France.
  • Valencia A; ICREA, 08010 Barcelona, Spain & Barcelona Supercomputing Center (BSC), 08034 Barcelona, Spain.
  • van der Lei J; Erasmus Universitair Medisch Centrum, 3015 CE Rotterdam, The Netherlands.
  • Vermeulen NPE; Vrije Universiteit Amsterdam, 1081 Amsterdam, The Netherlands.
  • Vock E; Boehringer Ingelheim International GmbH, 88379 Biberach an der Riss, Germany.
  • Wolber G; Inte:Ligand GmbH, 1070 Vienna, Austria.
  • Zamora I; Lead Molecular Design S.L., 08172 Sant Cugat del Vallès, Spain.
Nat Rev Drug Discov ; 16(12): 811-812, 2017 Dec.
Article em En | MEDLINE | ID: mdl-29026211
The sharing of legacy preclinical safety data among pharmaceutical companies and its integration with other information sources offers unprecedented opportunities to improve the early assessment of drug safety. Here, we discuss the experience of the eTOX project, which was established through the Innovative Medicines Initiative to explore this possibility.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Disseminação de Informação / Indústria Farmacêutica / Avaliação Pré-Clínica de Medicamentos / Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos Tipo de estudo: Etiology_studies / Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Disseminação de Informação / Indústria Farmacêutica / Avaliação Pré-Clínica de Medicamentos / Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos Tipo de estudo: Etiology_studies / Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article