Fragile sites and high-resolution chromosome studies in multiple endocrine neoplasia type 2A.
Cancer Genet Cytogenet
; 35(2): 273-7, 1988 Oct 15.
Article
em En
| MEDLINE
| ID: mdl-2902917
ABSTRACT
Affected individuals from four kindreds with multiple endocrine neoplasia type 2A syndrome (MEN-2A), were studied for the possible existence of a specific fragile site that might be associated with the MEN-2A gene. The chromosomes were also examined with high-resolution banding with particular emphasis on those chromosomes (#1, 10, 20, and 22) that have been implicated by previous studies from several laboratories as being associated with this disease. There was no evidence for a unique fragile site or a unique high-resolution banding pattern in subjects with MEN-2A. These findings, in combination with all previous cytogenetic studies, indicate that it is unlikely that current techniques will be useful in developing a simple cytogenetic test for this disease.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasia Endócrina Múltipla
/
Fragilidade Cromossômica
Limite:
Humans
Idioma:
En
Ano de publicação:
1988
Tipo de documento:
Article