Salamander spinal cord regeneration: The ultimate positive control in vertebrate spinal cord regeneration.
Dev Biol
; 432(1): 63-71, 2017 12 01.
Article
em En
| MEDLINE
| ID: mdl-29030146
ABSTRACT
Repairing injured tissues / organs is one of the major challenges for the maintenance of proper organ function in adulthood. In mammals, the central nervous system including the spinal cord, once established during embryonic development, has very limited capacity to regenerate. In contrast, salamanders such as axolotls can fully regenerate the injured spinal cord, making this a very powerful vertebrate model system for studying this process. Here we discuss the cellular and molecular requirements for spinal cord regeneration in the axolotl. The recent development of tools to test molecular function, including CRISPR-mediated gene editing, has lead to the identification of key players involved in the cell response to injury that ultimately leads to outgrowth of neural stem cells that are competent to replay the process of spinal cord development to replace the damaged/missing tissue.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Regeneração da Medula Espinal
/
Ambystoma mexicanum
Limite:
Animals
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article