Your browser doesn't support javascript.
loading
Omega-6 fatty acid biomarkers and incident type 2 diabetes: pooled analysis of individual-level data for 39 740 adults from 20 prospective cohort studies.
Wu, Jason H Y; Marklund, Matti; Imamura, Fumiaki; Tintle, Nathan; Ardisson Korat, Andres V; de Goede, Janette; Zhou, Xia; Yang, Wei-Sin; de Oliveira Otto, Marcia C; Kröger, Janine; Qureshi, Waqas; Virtanen, Jyrki K; Bassett, Julie K; Frazier-Wood, Alexis C; Lankinen, Maria; Murphy, Rachel A; Rajaobelina, Kalina; Del Gobbo, Liana C; Forouhi, Nita G; Luben, Robert; Khaw, Kay-Tee; Wareham, Nick; Kalsbeek, Anya; Veenstra, Jenna; Luo, Juhua; Hu, Frank B; Lin, Hung-Ju; Siscovick, David S; Boeing, Heiner; Chen, Tzu-An; Steffen, Brian; Steffen, Lyn M; Hodge, Allison; Eriksdottir, Gudny; Smith, Albert V; Gudnason, Vilmunder; Harris, Tamara B; Brouwer, Ingeborg A; Berr, Claudine; Helmer, Catherine; Samieri, Cecilia; Laakso, Markku; Tsai, Michael Y; Giles, Graham G; Nurmi, Tarja; Wagenknecht, Lynne; Schulze, Matthias B; Lemaitre, Rozenn N; Chien, Kuo-Liong; Soedamah-Muthu, Sabita S.
Afiliação
  • Wu JHY; The George Institute for Global Health, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia. Electronic address: jwu1@georgeinstitute.org.au.
  • Marklund M; Department of Public Health and Caring Sciences, Clinical Nutrition and Metabolism, Uppsala University, Uppsala, Sweden.
  • Imamura F; Medical Research Council Epidemiology Unit, University of Cambridge, Cambridge, UK.
  • Tintle N; Department of Mathematics and Statistics, Dordt College, Sioux Center, IA, USA.
  • Ardisson Korat AV; Department of Nutrition and Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
  • de Goede J; Division of Human Nutrition, Wageningen University, Wageningen, Netherlands.
  • Zhou X; School of Public Health, Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN, USA.
  • Yang WS; Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan.
  • de Oliveira Otto MC; Division of Epidemiology, Human Genetics and Environmental Sciences, The University of Texas Health Science Center, School of Public Health, Houston, TX, USA.
  • Kröger J; German Institute of Human Nutrition, Potsdam, Germany.
  • Qureshi W; Wake Forest University, Winston-Salem, NC, USA.
  • Virtanen JK; Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.
  • Bassett JK; Cancer Council Victoria, Melbourne, VIC, Australia.
  • Frazier-Wood AC; US Department of Agriculture/Agricultural Research Service, Children's Nutrition Research Center, Houston, TX, USA.
  • Lankinen M; Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.
  • Murphy RA; University of British Columbia, Vancouver, BC, Canada.
  • Rajaobelina K; University of Bordeaux, INSERM, Bordeaux Population Health Research Centre, UMR 1219, Bordeaux, France.
  • Del Gobbo LC; Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA.
  • Forouhi NG; Medical Research Council Epidemiology Unit, University of Cambridge, Cambridge, UK.
  • Luben R; Department of Public Health and Primary Care, School of Clinical Medicine, University of Cambridge, Cambridge, UK.
  • Khaw KT; Department of Public Health and Primary Care, School of Clinical Medicine, University of Cambridge, Cambridge, UK; Department of Mathematics and Statistics, Dordt College, Sioux Center, IA, USA.
  • Wareham N; Medical Research Council Epidemiology Unit, University of Cambridge, Cambridge, UK.
  • Kalsbeek A; Department of Mathematics and Statistics, Dordt College, Sioux Center, IA, USA; Department of Biology, Dordt College, Sioux Center, IA, USA.
  • Veenstra J; Department of Mathematics and Statistics, Dordt College, Sioux Center, IA, USA; Department of Biology, Dordt College, Sioux Center, IA, USA.
  • Luo J; Department of Epidemiology and Biostatistics, Indiana University, Bloomington, IN, USA.
  • Hu FB; Department of Nutrition and Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
  • Lin HJ; Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.
  • Siscovick DS; The New York Academy of Medicine, New York, NY, USA.
  • Boeing H; German Institute of Human Nutrition, Potsdam, Germany.
  • Chen TA; US Department of Agriculture/Agricultural Research Service, Children's Nutrition Research Center, Houston, TX, USA.
  • Steffen B; Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA.
  • Steffen LM; School of Public Health, Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN, USA.
  • Hodge A; Cancer Council Victoria, Melbourne, VIC, Australia.
  • Eriksdottir G; Icelandic Heart Institute, Kópavogur, Iceland.
  • Smith AV; Icelandic Heart Institute, Kópavogur, Iceland.
  • Gudnason V; Icelandic Heart Institute, Kópavogur, Iceland.
  • Harris TB; National Institute on Aging, Bethesda, MD, USA.
  • Brouwer IA; Health Sciences, Vrije Universiteit Amsterdam, Amsterdam, Netherlands.
  • Berr C; INSERM U1061, Neuropsychiatry: Epidemiological and Clinical Research, and Montpellier University Hospital, Montpellier University, Montpellier, France.
  • Helmer C; University of Bordeaux, INSERM, Bordeaux Population Health Research Centre, UMR 1219, Bordeaux, France.
  • Samieri C; University of Bordeaux, INSERM, Bordeaux Population Health Research Centre, UMR 1219, Bordeaux, France.
  • Laakso M; Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland.
  • Tsai MY; Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA.
  • Giles GG; Cancer Council Victoria, Melbourne, VIC, Australia.
  • Nurmi T; Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.
  • Wagenknecht L; Wake Forest University, Winston-Salem, NC, USA.
  • Schulze MB; German Institute of Human Nutrition, Potsdam, Germany.
  • Lemaitre RN; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
  • Chien KL; Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan; Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.
  • Soedamah-Muthu SS; Division of Human Nutrition, Wageningen University, Wageningen, Netherlands.
Lancet Diabetes Endocrinol ; 5(12): 965-974, 2017 12.
Article em En | MEDLINE | ID: mdl-29032079
ABSTRACT

BACKGROUND:

The metabolic effects of omega-6 polyunsaturated fatty acids (PUFAs) remain contentious, and little evidence is available regarding their potential role in primary prevention of type 2 diabetes. We aimed to assess the associations of linoleic acid and arachidonic acid biomarkers with incident type 2 diabetes.

METHODS:

We did a pooled analysis of new, harmonised, individual-level analyses for the biomarkers linoleic acid and its metabolite arachidonic acid and incident type 2 diabetes. We analysed data from 20 prospective cohort studies from ten countries (Iceland, the Netherlands, the USA, Taiwan, the UK, Germany, Finland, Australia, Sweden, and France), with biomarkers sampled between 1970 and 2010. Participants included in the analyses were aged 18 years or older and had data available for linoleic acid and arachidonic acid biomarkers at baseline. We excluded participants with type 2 diabetes at baseline. The main outcome was the association between omega-6 PUFA biomarkers and incident type 2 diabetes. We assessed the relative risk of type 2 diabetes prospectively for each cohort and lipid compartment separately using a prespecified analytic plan for exposures, covariates, effect modifiers, and analysis, and the findings were then pooled using inverse-variance weighted meta-analysis.

FINDINGS:

Participants were 39 740 adults, aged (range of cohort means) 49-76 years with a BMI (range of cohort means) of 23·3-28·4 kg/m2, who did not have type 2 diabetes at baseline. During a follow-up of 366 073 person-years, we identified 4347 cases of incident type 2 diabetes. In multivariable-adjusted pooled analyses, higher proportions of linoleic acid biomarkers as percentages of total fatty acid were associated with a lower risk of type 2 diabetes overall (risk ratio [RR] per interquintile range 0·65, 95% CI 0·60-0·72, p<0·0001; I2=53·9%, pheterogeneity=0·002). The associations between linoleic acid biomarkers and type 2 diabetes were generally similar in different lipid compartments, including phospholipids, plasma, cholesterol esters, and adipose tissue. Levels of arachidonic acid biomarker were not significantly associated with type 2 diabetes risk overall (RR per interquintile range 0·96, 95% CI 0·88-1·05; p=0·38; I2=63·0%, pheterogeneity<0·0001). The associations between linoleic acid and arachidonic acid biomarkers and the risk of type 2 diabetes were not significantly modified by any prespecified potential sources of heterogeneity (ie, age, BMI, sex, race, aspirin use, omega-3 PUFA levels, or variants of the FADS gene; all pheterogeneity≥0·13).

INTERPRETATION:

Findings suggest that linoleic acid has long-term benefits for the prevention of type 2 diabetes and that arachidonic acid is not harmful.

FUNDING:

Funders are shown in the appendix.
Assuntos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ácidos Graxos Ômega-6 / Diabetes Mellitus Tipo 2 Tipo de estudo: Diagnostic_studies / Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Limite: Adult / Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ácidos Graxos Ômega-6 / Diabetes Mellitus Tipo 2 Tipo de estudo: Diagnostic_studies / Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Limite: Adult / Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article