Long-Term Exposure to Ambient Air Pollution and Incidence of Postmenopausal Breast Cancer in 15 European Cohorts within the ESCAPE Project.
Environ Health Perspect
; 125(10): 107005, 2017 10 13.
Article
em En
| MEDLINE
| ID: mdl-29033383
ABSTRACT
BACKGROUND:
Epidemiological evidence on the association between ambient air pollution and breast cancer risk is inconsistent.OBJECTIVE:
We examined the association between long-term exposure to ambient air pollution and incidence of postmenopausal breast cancer in European women.METHODS:
In 15 cohorts from nine European countries, individual estimates of air pollution levels at the residence were estimated by standardized land-use regression models developed within the European Study of Cohorts for Air Pollution Effects (ESCAPE) and Transport related Air Pollution and Health impacts Integrated Methodologies for Assessing Particulate Matter (TRANSPHORM) projects particulate matter (PM) ≤2.5µm, ≤10µm, and 2.510µm in diameter (PM2.5, PM10, and PMcoarse, respectively); PM2.5 absorbance; nitrogen oxides (NO2 and NOx); traffic intensity; and elemental composition of PM. We estimated cohort-specific associations between breast cancer and air pollutants using Cox regression models, adjusting for major lifestyle risk factors, and pooled cohort-specific estimates using random-effects meta-analyses.RESULTS:
Of 74,750 postmenopausal women included in the study, 3,612 developed breast cancer during 991,353 person-years of follow-up. We found positive and statistically insignificant associations between breast cancer and PM2.5 {hazard ratio (HR)=1.08 [95% confidence interval (CI) 0.77, 1.51] per 5 µg/m3}, PM10 [1.07 (95% CI 0.89, 1.30) per 10 µg/m3], PMcoarse[1.20 (95% CI 0.96, 1.49 per 5 µg/m3], and NO2 [1.02 (95% CI 0.98, 1.07 per 10 µg/m3], and a statistically significant association with NOx [1.04 (95% CI 1.00, 1.08) per 20 µg/m3, p=0.04].CONCLUSIONS:
We found suggestive evidence of an association between ambient air pollution and incidence of postmenopausal breast cancer in European women. https//doi.org/10.1289/EHP1742.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Mama
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Pós-Menopausa
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Poluição do Ar
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Exposição Ambiental
Tipo de estudo:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
/
Systematic_reviews
Limite:
Aged
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Female
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Humans
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Middle aged
País/Região como assunto:
Europa
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article