Nanomedicine for Intranasal Delivery to Improve Brain Uptake.
Curr Drug Deliv
; 15(4): 461-469, 2018.
Article
em En
| MEDLINE
| ID: mdl-29034836
ABSTRACT
Intranasal drug delivery system provides distinct advantage over conventional drug delivery system for a drug that is pharmacokenetically or biologically unstable. Major concern for the treatment of central nervous system diseases is, low concentration of therapeutically active molecule within brain as blood brain barrier is creating obstacle, where intranasal drug delivery provides direct transport of therapeutically active moiety into brain via olfactory or trigeminal pathway. Nasal mucosa provides distinct advantages like improved bioavailability, law dose and quick onset of action and high patient compliance, and the major disadvantage is residence time of drug and irreversible entrapment of drug. This article provides anatomical and physiological information about nasal route and various factors. Article discusses various types of nanoparticles used intranasally and moreover article also emphasizes patents, formulation under development and some.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Encéfalo
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Preparações Farmacêuticas
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Sistemas de Liberação de Medicamentos
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Nanomedicina
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Nanopartículas
Limite:
Humans
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article