Improving myocardial fractional flow reserve in coronary atherosclerosis via CX37 gene silence: a preclinical validation study in pigs.

Guo, Suxia; Yang, Ying; Yang, Zhenyu; You, Huayan; Shi, Yunke; Hu, Zhao; Meng, Zhaohui; Xiao, Jianming

Guo, Suxia; Yang, Ying; Yang, Zhenyu; You, Huayan; Shi, Yunke; Hu, Zhao; Meng, Zhaohui; Xiao, Jianming.

Afiliação

Guo S; Department of Cardiology, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.
Yang Y; Department of Cardiology, Affiliated People's Hospital of Nanjing Medical University in Wuxi and People's Hospital of Wuxi City, Wuxi, Jiangsu, China.
Yang Z; Department of Cardiology, Affiliated People's Hospital of Nanjing Medical University in Wuxi and People's Hospital of Wuxi City, Wuxi, Jiangsu, China.
You H; Department of Cardiology, Affiliated People's Hospital of Nanjing Medical University in Wuxi and People's Hospital of Wuxi City, Wuxi, Jiangsu, China.
Shi Y; Department of Cardiology, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.
Hu Z; Department of Cardiology, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.
Meng Z; Department of Cardiology, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.
Xiao J; Department of Cardiology, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.

Interact Cardiovasc Thorac Surg ; 26(1): 139-145, 2018 01 01.

Article em En | MEDLINE | ID: mdl-29049831

Assuntos

Conexinas/genética; Estenose Coronária/genética; Reserva Fracionada de Fluxo Miocárdico/fisiologia; Regulação da Expressão Gênica; Placa Aterosclerótica/genética; RNA/genética; Animais; Western Blotting; Conexinas/biossíntese; Estenose Coronária/metabolismo; Estenose Coronária/fisiopatologia; Modelos Animais de Doenças; Humanos; Masculino; Placa Aterosclerótica/metabolismo; Placa Aterosclerótica/fisiopatologia; Reação em Cadeia da Polimerase; Valor Preditivo dos Testes; Elementos Silenciadores Transcricionais; Suínos; Proteína alfa-4 de Junções Comunicantes

Palavras-chave

Atherosclerosis; CX37; FFR; Fractional flow reserve; Gene therapy; SiRNA

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: RNA / Regulação da Expressão Gênica / Conexinas / Estenose Coronária / Reserva Fracionada de Fluxo Miocárdico / Placa Aterosclerótica Tipo de estudo: Prognostic_studies Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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