New triterpene saponins from the roots of Acacia macrostachya (Mimosaceae).

Tchoukoua, Abdou; Tabopda, Turibio Kuiate; Usukhbayar, Narandulam; Kimura, Ken-Ichi; Kwon, Eunsang; Momma, Hiroyuki; Koseki, Takuya; Shiono, Yoshihito; Ngadjui, Bonaventure Tchaleu

Tchoukoua, Abdou; Tabopda, Turibio Kuiate; Usukhbayar, Narandulam; Kimura, Ken-Ichi; Kwon, Eunsang; Momma, Hiroyuki; Koseki, Takuya; Shiono, Yoshihito; Ngadjui, Bonaventure Tchaleu.

Afiliação

Tchoukoua A; a Department of Organic Chemistry , University of Yaounde 1 , Yaounde , Cameroon.
Tabopda TK; b Faculty of Agriculture , Yamagata University , Tsuruoka , Japan.
Usukhbayar N; a Department of Organic Chemistry , University of Yaounde 1 , Yaounde , Cameroon.
Kimura KI; c The United Graduate School of Agricultural Sciences , Iwate University , Morioka , Japan.
Kwon E; c The United Graduate School of Agricultural Sciences , Iwate University , Morioka , Japan.
Momma H; d Research and Analytical Center for Giant Molecules, Graduate School of Science , Tohoku University , Sendai , Japan.
Koseki T; d Research and Analytical Center for Giant Molecules, Graduate School of Science , Tohoku University , Sendai , Japan.
Shiono Y; b Faculty of Agriculture , Yamagata University , Tsuruoka , Japan.
Ngadjui BT; b Faculty of Agriculture , Yamagata University , Tsuruoka , Japan.

Biosci Biotechnol Biochem ; 81(12): 2261-2267, 2017 Dec.

Article em En | MEDLINE | ID: mdl-29052455

ABSTRACT

ABSTRACT

Four new oleanane-type saponins, macrostachyaosides A, B, C, and D (1-4) were isolated from the roots of Acacia macrostachya. Their structures were elucidated on the basis of extensive 1D- and 2D-NMR data and HR-ESI-MS analyses. At concentrations of 100 µM of each compounds, none of the tested compounds caused a significant growth reduction against HL60 cells.

Assuntos

Acacia/química; Antineoplásicos Fitogênicos/química; Antineoplásicos Fitogênicos/farmacologia; Raízes de Plantas/química; Saponinas/química; Triterpenos/química; Triterpenos/farmacologia; Proliferação de Células/efeitos dos fármacos; Células HL-60; Humanos

Palavras-chave

Acacia macrostachya; Mimosaceae; macrostachyaosides; triterpene saponins

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Saponinas / Triterpenos / Raízes de Plantas / Acacia / Antineoplásicos Fitogênicos Limite: Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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