Your browser doesn't support javascript.
loading
Immunogenomic Classification of Colorectal Cancer and Therapeutic Implications.
Roelands, Jessica; Kuppen, Peter J K; Vermeulen, Louis; Maccalli, Cristina; Decock, Julie; Wang, Ena; Marincola, Francesco M; Bedognetti, Davide; Hendrickx, Wouter.
Afiliação
  • Roelands J; Tumor Biology, Immunology, and Therapy Section, Immunology, Inflammation, and Metabolism Department, Division of Translational Medicine, Sidra Medical and Research Center, PO Box 26999 Doha, Qatar. jroelands@sidra.org.
  • Kuppen PJK; Department of Surgery, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands. jroelands@sidra.org.
  • Vermeulen L; Department of Surgery, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands. P.J.K.Kuppen@lumc.nl.
  • Maccalli C; Academic Medical Center Amsterdam, Center for Experimental Molecular Medicine, 1105AZ Amsterdam, The Netherlands. l.vermeulen@amc.uva.nl.
  • Decock J; Tumor Biology, Immunology, and Therapy Section, Immunology, Inflammation, and Metabolism Department, Division of Translational Medicine, Sidra Medical and Research Center, PO Box 26999 Doha, Qatar. cmaccalli@sidra.org.
  • Wang E; Qatar Biomedical Research Institute, Hamad Bin Khalifa University, Qatar Foundation, PO Box 5825 Doha, Qatar. jdecock@hbku.edu.qa.
  • Marincola FM; Office of the Chief Research Officer (CRO), Sidra Medical and Research Center, PO Box 26999 Doha, Qatar. ewang@sidra.org.
  • Bedognetti D; Office of the Chief Research Officer (CRO), Sidra Medical and Research Center, PO Box 26999 Doha, Qatar. francesco.marincola@abbvie.com.
  • Hendrickx W; Tumor Biology, Immunology, and Therapy Section, Immunology, Inflammation, and Metabolism Department, Division of Translational Medicine, Sidra Medical and Research Center, PO Box 26999 Doha, Qatar. dbedognetti@sidra.org.
Int J Mol Sci ; 18(10)2017 Oct 24.
Article em En | MEDLINE | ID: mdl-29064420
The immune system has a substantial effect on colorectal cancer (CRC) progression. Additionally, the response to immunotherapeutics and conventional treatment options (e.g., chemotherapy, radiotherapy and targeted therapies) is influenced by the immune system. The molecular characterization of colorectal cancer (CRC) has led to the identification of favorable and unfavorable immunological attributes linked to clinical outcome. With the definition of consensus molecular subtypes (CMSs) based on transcriptomic profiles, multiple characteristics have been proposed to be responsible for the development of the tumor immune microenvironment and corresponding mechanisms of immune escape. In this review, a detailed description of proposed immune phenotypes as well as their interaction with different therapeutic modalities will be provided. Finally, possible strategies to shift the CRC immune phenotype towards a reactive, anti-tumor orientation are proposed per CMS.
Assuntos
Palavras-chave

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Colorretais / Sistema Imunitário Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Colorretais / Sistema Imunitário Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article