Tumor Progression of Non-Small Cell Lung Cancer Controlled by Albumin and Micellar Nanoparticles of Itraconazole, a Multitarget Angiogenesis Inhibitor.

Zhang, Ling; Liu, Zhengsheng; Yang, Kuan; Kong, Chao; Liu, Chun; Chen, Huijun; Huang, Jinfeng; Qian, Feng

Zhang, Ling; Liu, Zhengsheng; Yang, Kuan; Kong, Chao; Liu, Chun; Chen, Huijun; Huang, Jinfeng; Qian, Feng.

Afiliação

Zhang L; School of Pharmaceutical Sciences and Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Tsinghua University , Beijing 100084, P. R. China.
Liu Z; School of Pharmaceutical Sciences and Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Tsinghua University , Beijing 100084, P. R. China.
Yang K; School of Pharmaceutical Sciences and Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Tsinghua University , Beijing 100084, P. R. China.
Kong C; School of Pharmaceutical Sciences and Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Tsinghua University , Beijing 100084, P. R. China.
Liu C; School of Pharmaceutical Sciences and Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Tsinghua University , Beijing 100084, P. R. China.
Chen H; School of Pharmaceutical Sciences and Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Tsinghua University , Beijing 100084, P. R. China.
Huang J; Department of Thoracic Surgery, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medicine College , Beijing 100021, P. R. China.
Qian F; School of Pharmaceutical Sciences and Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Tsinghua University , Beijing 100084, P. R. China.

Mol Pharm ; 14(12): 4705-4713, 2017 12 04.

Article em En | MEDLINE | ID: mdl-29068216

Assuntos

Inibidores da Angiogênese/farmacologia; Antineoplásicos/farmacologia; Carcinoma Pulmonar de Células não Pequenas/tratamento farmacológico; Itraconazol/farmacologia; Neoplasias Pulmonares/tratamento farmacológico; Albuminas/química; Inibidores da Angiogênese/uso terapêutico; Animais; Antineoplásicos/uso terapêutico; Carcinoma Pulmonar de Células não Pequenas/patologia; Linhagem Celular Tumoral; Proliferação de Células/efeitos dos fármacos; Progressão da Doença; Humanos; Injeções Intravenosas; Itraconazol/uso terapêutico; Pulmão/efeitos dos fármacos; Pulmão/patologia; Neoplasias Pulmonares/patologia; Masculino; Camundongos; Camundongos Endogâmicos NOD; Camundongos SCID; Micelas; Nanopartículas/química; Paclitaxel/farmacologia; Paclitaxel/uso terapêutico; Polietilenoglicóis/química; Ratos; Ratos Sprague-Dawley; Transdução de Sinais/efeitos dos fármacos; Ensaios Antitumorais Modelo de Xenoenxerto

Palavras-chave

NSCLC; angiogenesis; itraconazole; nanoparticle formulations; pharmacokinetics

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Itraconazol / Carcinoma Pulmonar de Células não Pequenas / Inibidores da Angiogênese / Neoplasias Pulmonares / Antineoplásicos Tipo de estudo: Prognostic_studies Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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