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Small-molecule inhibitors directly target CARD9 and mimic its protective variant in inflammatory bowel disease.
Leshchiner, Elizaveta S; Rush, Jason S; Durney, Michael A; Cao, Zhifang; Dancík, Vlado; Chittick, Benjamin; Wu, Huixian; Petrone, Adam; Bittker, Joshua A; Phillips, Andrew; Perez, Jose R; Shamji, Alykhan F; Kaushik, Virendar K; Daly, Mark J; Graham, Daniel B; Schreiber, Stuart L; Xavier, Ramnik J.
Afiliação
  • Leshchiner ES; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138.
  • Rush JS; Center for the Science of Therapeutics, Broad Institute, Cambridge, MA 02142.
  • Durney MA; Center for the Development of Therapeutics, Broad Institute, Cambridge, MA 02142.
  • Cao Z; Center for the Development of Therapeutics, Broad Institute, Cambridge, MA 02142.
  • Dancík V; Gastrointestinal Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114.
  • Chittick B; Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114.
  • Wu H; Infectious Disease and Microbiome Program, Broad Institute, Cambridge, MA 02142.
  • Petrone A; Center for the Science of Therapeutics, Broad Institute, Cambridge, MA 02142.
  • Bittker JA; Center for the Science of Therapeutics, Broad Institute, Cambridge, MA 02142.
  • Phillips A; Center for the Science of Therapeutics, Broad Institute, Cambridge, MA 02142.
  • Perez JR; Center for the Development of Therapeutics, Broad Institute, Cambridge, MA 02142.
  • Shamji AF; Center for the Development of Therapeutics, Broad Institute, Cambridge, MA 02142.
  • Kaushik VK; Center for the Development of Therapeutics, Broad Institute, Cambridge, MA 02142.
  • Daly MJ; Center for the Development of Therapeutics, Broad Institute, Cambridge, MA 02142.
  • Graham DB; Center for the Science of Therapeutics, Broad Institute, Cambridge, MA 02142.
  • Schreiber SL; Center for the Development of Therapeutics, Broad Institute, Cambridge, MA 02142.
  • Xavier RJ; Medical and Population Genetics Program, Broad Institute, Cambridge, MA 02142.
Proc Natl Acad Sci U S A ; 114(43): 11392-11397, 2017 10 24.
Article em En | MEDLINE | ID: mdl-29073062
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Variação Genética / Ensaio de Imunoadsorção Enzimática / Doenças Inflamatórias Intestinais / Proteínas Adaptadoras de Sinalização CARD Tipo de estudo: Diagnostic_studies Limite: Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Variação Genética / Ensaio de Imunoadsorção Enzimática / Doenças Inflamatórias Intestinais / Proteínas Adaptadoras de Sinalização CARD Tipo de estudo: Diagnostic_studies Limite: Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article