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CRISPR-Cas9-mediated saturated mutagenesis screen predicts clinical drug resistance with improved accuracy.
Ma, Leyuan; Boucher, Jeffrey I; Paulsen, Janet; Matuszewski, Sebastian; Eide, Christopher A; Ou, Jianhong; Eickelberg, Garrett; Press, Richard D; Zhu, Lihua Julie; Druker, Brian J; Branford, Susan; Wolfe, Scot A; Jensen, Jeffrey D; Schiffer, Celia A; Green, Michael R; Bolon, Daniel N.
Afiliação
  • Ma L; Department of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School, Worcester, MA 01605.
  • Boucher JI; Howard Hughes Medical Institute, University of Massachusetts Medical School, Worcester, MA 01605.
  • Paulsen J; Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605.
  • Matuszewski S; Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605.
  • Eide CA; School of Life Sciences, École Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland.
  • Ou J; Swiss Institute of Bioinformatics, 1015 Lausanne, Switzerland.
  • Eickelberg G; Knight Cancer Institute, Division of Hematology and Medical Oncology, Oregon Health & Science University, Portland, OR 97239.
  • Press RD; Howard Hughes Medical Institute, Oregon Health & Science University, Portland, OR 97239.
  • Zhu LJ; Department of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School, Worcester, MA 01605.
  • Druker BJ; Knight Cancer Institute, Department of Pathology, Oregon Health & Science University, Portland, OR 97239.
  • Branford S; Knight Cancer Institute, Department of Pathology, Oregon Health & Science University, Portland, OR 97239.
  • Wolfe SA; Department of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School, Worcester, MA 01605.
  • Jensen JD; Programs in Molecular Medicine and Bioinformatics and Integrative Biology, University of Massachusetts Medical School, Worcester, MA 01605.
  • Schiffer CA; Knight Cancer Institute, Division of Hematology and Medical Oncology, Oregon Health & Science University, Portland, OR 97239.
  • Green MR; Howard Hughes Medical Institute, Oregon Health & Science University, Portland, OR 97239.
  • Bolon DN; Department of Genetics and Molecular Pathology, Centre for Cancer Biology, SA Pathology, Adelaide, SA 5000, Australia.
Proc Natl Acad Sci U S A ; 114(44): 11751-11756, 2017 10 31.
Article em En | MEDLINE | ID: mdl-29078326
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Mutagênese / Resistencia a Medicamentos Antineoplásicos / Sistemas CRISPR-Cas Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals Idioma: En Ano de publicação: 2017 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Mutagênese / Resistencia a Medicamentos Antineoplásicos / Sistemas CRISPR-Cas Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals Idioma: En Ano de publicação: 2017 Tipo de documento: Article