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[Oxidative damage effects induced by CdTe quantum dots in mice].
Xie, G Y; Chen, W; Wang, Q K; Cheng, X R; Xu, J N; Huang, P L.
Afiliação
  • Xie GY; National Insititue of Occupational Health and Poison Control, Chinese Center for Disease Control and Prevention, Beijing 100050, China.
Article em Zh | MEDLINE | ID: mdl-29081095
ABSTRACT

Objective:

To investigate Oxidative damage effects induced by CdTe Quantum Dots (QDs) in mice.

Methods:

40 ICR mice were randomly divided into 5 groups one control group (normal saline) ; four CdTe QDs (exposed by intravenous injection of 0.2 ml of CdTe QDs at the concentration of 0、0.5、5.0、50.0 and 500.0 nmol/ml respectively) . After 24 h, the mice were decapitated and the blood was collected for serum biochemically indexes、hematology indexes, the activities of SOD、GSH-Px and the concentration of MDA were all detected.

Results:

The results showed in the four CdTe QDs exposure groups, the level of CRE、PLT and the concentration of MDA were all significantly lower than those of the control group (P<0.05 or P<0.01) ; the activities GSH-Px in 50.0 and 500.0 nmol/ml CdTe QDs group were significantly higher than those of control group (P<0.01) .

Conclusion:

It was suggested that CdTe QDs at 0.5 nmol/ml could induce Oxidative damage effects in mice.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Telúrio / Estresse Oxidativo / Compostos de Cádmio / Pontos Quânticos / Fígado Limite: Animals Idioma: Zh Ano de publicação: 2017 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Telúrio / Estresse Oxidativo / Compostos de Cádmio / Pontos Quânticos / Fígado Limite: Animals Idioma: Zh Ano de publicação: 2017 Tipo de documento: Article