[Oxidative damage effects induced by CdTe quantum dots in mice].
Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi
; 35(7): 487-490, 2017 Jul 20.
Article
em Zh
| MEDLINE
| ID: mdl-29081095
ABSTRACT
Objective:
To investigate Oxidative damage effects induced by CdTe Quantum Dots (QDs) in mice.Methods:
40 ICR mice were randomly divided into 5 groups one control group (normal saline) ; four CdTe QDs (exposed by intravenous injection of 0.2 ml of CdTe QDs at the concentration of 0ã0.5ã5.0ã50.0 and 500.0 nmol/ml respectively) . After 24 h, the mice were decapitated and the blood was collected for serum biochemically indexesãhematology indexes, the activities of SODãGSH-Px and the concentration of MDA were all detected.Results:
The results showed in the four CdTe QDs exposure groups, the level of CREãPLT and the concentration of MDA were all significantly lower than those of the control group (P<0.05 or P<0.01) ; the activities GSH-Px in 50.0 and 500.0 nmol/ml CdTe QDs group were significantly higher than those of control group (P<0.01) .Conclusion:
It was suggested that CdTe QDs at 0.5 nmol/ml could induce Oxidative damage effects in mice.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Telúrio
/
Estresse Oxidativo
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Compostos de Cádmio
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Pontos Quânticos
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Fígado
Limite:
Animals
Idioma:
Zh
Ano de publicação:
2017
Tipo de documento:
Article