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[Risk-factor analysis of poor graft function after allogeneic hematopoietic stem cell transplantation for severe aplastic anemia].
Shi, C Y; Mamal, Z H; Liu, X X; Wu, L H; Xia, D N; Nie, Y R; Lai, F Q; Duan, H W; Xiao, Z J; Jiang, Y H; Li, Y; Xiao, Yang.
Afiliação
  • Shi CY; Department of Hematology, General Hospital of Guangzhou Military Command of PLA, Southern Medical University, Guangzhou 510015, China.
  • Xiao Y; Department of Hematology, General Hospital of Guangzhou Military Command of PLA, Southern Medical University, Guangzhou 510015, China.
Zhonghua Xue Ye Xue Za Zhi ; 38(9): 761-766, 2017 Sep 14.
Article em Zh | MEDLINE | ID: mdl-29081192
Objective: To investigate the risk factors of poor graft function (PGF) after allogeneic hematopoietic stem cell transplantation (allo-HSCT) for severe aplastic anemia (SAA) . Methods: Clinical data from 111 SAA patients who received allo-HSCT were analyzed retrospectively. Factors including age, gender, interval to transplantation, the level of serum ferritin before transplantation were analyzed by Cox multivariate regression analysis. Results: Among the 111 patients who underwent allo-HSCT, 16 developed PGF (14.4%) . Multivariate analysis showed donor type (HR=2.656, 95%CI 1.204-5.858, P= 0.016) and the level of serum ferritin before tansplantation (HR=3.170, 95%CI 1.400-7.180, P=0.006) were significant risk factors for PGF. Conclusion: Unrelated donor transplantation and the high level of serum ferritin before transplantation are risk factors for PGF.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Anemia Aplástica Tipo de estudo: Etiology_studies / Observational_studies / Risk_factors_studies Limite: Humans Idioma: Zh Ano de publicação: 2017 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Anemia Aplástica Tipo de estudo: Etiology_studies / Observational_studies / Risk_factors_studies Limite: Humans Idioma: Zh Ano de publicação: 2017 Tipo de documento: Article