Effects of telmisartan on paroxysmal atrial fibrillation in hypertensive patients.
Pak J Pharm Sci
; 30(5): 1651-1655, 2017 Sep.
Article
em En
| MEDLINE
| ID: mdl-29084686
ABSTRACT
This study examined the effects and mechanisms of telmisartan in hypertensive patients with paroxysmal atrial fibrillation (PAF). Hypertensive patients with PAF (n=120) were randomized into test (telmisartan) and control (amlodipine besilate) groups. The pretreatment and post treatment left atrial dimension (LAD), high-sensitivity C-reactive protein (hs-CRP) levels, heart rate, blood pressure (BP), and recurrence times of atrial fibrillation (AF) were recorded. The pretreatment and post treatment heart rates and BPs did not differ in either group (P>0.05). The post treatment systolic BP (SBP) and diastolic BP (DBP) did not differ between the groups (SBP test, 132±5mmHg; control, 133±6 mmHg; DBP test, 82±4 mmHg; control, 83±4mmHg). The LAD (test, 36.7±5.1 mm; control, 31.3±4.1mm) and hs-CRP (test, 5.6±2.6mg/L; control, 3.1±1.9mg/L) levels declined significantly (P>0.05) after treatment in the telmisartan group but not in the control group. After treatment, the LAD (test, 31.3±4.1mm; control, 36.2±4.6mm), hs-CRP (test, 3.1±1.9 mg/L; control, 5.2±2.3mg/L) levels, and AF recurrence times were markedly lower in the test group (22) compared with the control group (44). Thus, telmisartan reduced the AF recurrence rates, LAD, and hs-CRP levels.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fibrilação Atrial
/
Pressão Sanguínea
/
Telmisartan
/
Frequência Cardíaca
/
Hipertensão
/
Antiarrítmicos
/
Anti-Hipertensivos
Tipo de estudo:
Clinical_trials
/
Diagnostic_studies
Limite:
Female
/
Humans
/
Male
/
Middle aged
País/Região como assunto:
Asia
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article