Phosphate Promotes the Recovery of Mycobacterium tuberculosis ß-Lactamase from Clavulanic Acid Inhibition.

Elings, Wouter; Tassoni, Raffaella; van der Schoot, Steven A; Luu, Wendy; Kynast, Josef P; Dai, Lin; Blok, Anneloes J; Timmer, Monika; Florea, Bogdan I; Pannu, Navraj S; Ubbink, Marcellus

Elings, Wouter; Tassoni, Raffaella; van der Schoot, Steven A; Luu, Wendy; Kynast, Josef P; Dai, Lin; Blok, Anneloes J; Timmer, Monika; Florea, Bogdan I; Pannu, Navraj S; Ubbink, Marcellus.

Afiliação

Elings W; Leiden Institute of Chemistry, Leiden University , Einsteinweg 55, Leiden, The Netherlands.
Tassoni R; Leiden Institute of Chemistry, Leiden University , Einsteinweg 55, Leiden, The Netherlands.
van der Schoot SA; Leiden Institute of Chemistry, Leiden University , Einsteinweg 55, Leiden, The Netherlands.
Luu W; Leiden Institute of Chemistry, Leiden University , Einsteinweg 55, Leiden, The Netherlands.
Kynast JP; Leiden Institute of Chemistry, Leiden University , Einsteinweg 55, Leiden, The Netherlands.
Dai L; Leiden Institute of Chemistry, Leiden University , Einsteinweg 55, Leiden, The Netherlands.
Blok AJ; Leiden Institute of Chemistry, Leiden University , Einsteinweg 55, Leiden, The Netherlands.
Timmer M; Leiden Institute of Chemistry, Leiden University , Einsteinweg 55, Leiden, The Netherlands.
Florea BI; Leiden Institute of Chemistry, Leiden University , Einsteinweg 55, Leiden, The Netherlands.
Pannu NS; Leiden Institute of Chemistry, Leiden University , Einsteinweg 55, Leiden, The Netherlands.
Ubbink M; Leiden Institute of Chemistry, Leiden University , Einsteinweg 55, Leiden, The Netherlands.

Biochemistry ; 56(47): 6257-6267, 2017 11 28.

Article em En | MEDLINE | ID: mdl-29087696

Assuntos

Ácido Clavulânico/farmacologia; Farmacorresistência Bacteriana/efeitos dos fármacos; Mycobacterium tuberculosis/efeitos dos fármacos; Fosfatos/farmacologia; Tuberculose/tratamento farmacológico; Inibidores de beta-Lactamases/farmacologia; beta-Lactamases/química; Sítios de Ligação; Sinergismo Farmacológico; Humanos; Hidrólise; Testes de Sensibilidade Microbiana; Modelos Moleculares; Tuberculose/microbiologia

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fosfatos / Tuberculose / Beta-Lactamases / Ácido Clavulânico / Farmacorresistência Bacteriana / Inibidores de beta-Lactamases / Mycobacterium tuberculosis Limite: Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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