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Membrane dynamics and organelle biogenesis-lipid pipelines and vesicular carriers.
Stefan, Christopher J; Trimble, William S; Grinstein, Sergio; Drin, Guillaume; Reinisch, Karin; De Camilli, Pietro; Cohen, Sarah; Valm, Alex M; Lippincott-Schwartz, Jennifer; Levine, Tim P; Iaea, David B; Maxfield, Frederick R; Futter, Clare E; Eden, Emily R; Judith, Delphine; van Vliet, Alexander R; Agostinis, Patrizia; Tooze, Sharon A; Sugiura, Ayumu; McBride, Heidi M.
Afiliação
  • Stefan CJ; MRC Laboratory for Molecular Cell Biology, University College London, Gower Street, London, WC1E 6BT, UK. c.stefan@ucl.ac.uk.
  • Trimble WS; Cell Biology Program, The Hospital for Sick Children and Department of Biochemistry, University of Toronto, Toronto, Canada. wtrimble@sickkids.ca.
  • Grinstein S; Cell Biology Program, The Hospital for Sick Children and Department of Biochemistry, University of Toronto, Toronto, Canada. sergio.grinstein@sickkids.ca.
  • Drin G; Université Côte d'Azur, CNRS, Institut de Pharmacologie Moléculaire et Cellulaire, Valbonne, France. drin@ipmc.cnrs.fr.
  • Reinisch K; Department of Cell Biology, Yale University School of Medicine, New Haven, CT, 06520, USA. karin.reinisch@yale.edu.
  • De Camilli P; Department of Neuroscience and Cell Biology, Howard Hughes Medical Institute, Kavli Institute for Neuroscience and Program in Cellular Neuroscience, Neurodegeneration, and Repair, Yale University School of Medicine, New Haven, CT, 06510, USA. pietro.decamilli@yale.edu.
  • Cohen S; NICHD, NIH, Bethesda, MD, USA.
  • Valm AM; NICHD, NIH, Bethesda, MD, USA.
  • Lippincott-Schwartz J; HHMI Janelia Research Campus, Ashburn, VA, USA. lippincottschwartzj@janelia.hhmi.org.
  • Levine TP; UCL Institute of Ophthalmology, 11-43 Bath Street, London, EC1V 9EL, UK. tim.levine@ucl.ac.uk.
  • Iaea DB; Genentech, 1 DNA Way, South San Francisco, CA, 94080, USA.
  • Maxfield FR; Department of Biochemistry, Weill Cornell Medical College, 1300 York Ave, New York, NY, 10065, USA. frmaxfie@med.cornell.edu.
  • Futter CE; UCL Institute of Ophthalmology, 11-43 Bath Street, London, EC1V 9EL, UK. c.futter@ucl.ac.uk.
  • Eden ER; UCL Institute of Ophthalmology, 11-43 Bath Street, London, EC1V 9EL, UK. e.eden@ucl.ac.uk.
  • Judith D; Molecular Cell Biology of Autophagy Laboratory, The Francis Crick Institute, London, UK.
  • van Vliet AR; Molecular Cell Biology of Autophagy Laboratory, The Francis Crick Institute, London, UK.
  • Agostinis P; Laboratory of Cell Death Research and Therapy, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium.
  • Tooze SA; Laboratory of Cell Death Research and Therapy, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium.
  • Sugiura A; Molecular Cell Biology of Autophagy Laboratory, The Francis Crick Institute, London, UK. sharon.tooze@crick.ac.uk.
  • McBride HM; Kobe University Graduate School of Medicine, 1-5-6 Minatojima-minamimachi, Chuo-ku, Kobe, Hyogo, 650-0047, Japan.
BMC Biol ; 15(1): 102, 2017 10 31.
Article em En | MEDLINE | ID: mdl-29089042
ABSTRACT
Discoveries spanning several decades have pointed to vital membrane lipid trafficking pathways involving both vesicular and non-vesicular carriers. But the relative contributions for distinct membrane delivery pathways in cell growth and organelle biogenesis continue to be a puzzle. This is because lipids flow from many sources and across many paths via transport vesicles, non-vesicular transfer proteins, and dynamic interactions between organelles at membrane contact sites. This forum presents our latest understanding, appreciation, and queries regarding the lipid transport mechanisms necessary to drive membrane expansion during organelle biogenesis and cell growth.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Biogênese de Organelas / Ciclo Celular / Metabolismo dos Lipídeos Idioma: En Ano de publicação: 2017 Tipo de documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Biogênese de Organelas / Ciclo Celular / Metabolismo dos Lipídeos Idioma: En Ano de publicação: 2017 Tipo de documento: Article