Genomic imprinting of Xist by maternal H3K27me3.
Genes Dev
; 31(19): 1927-1932, 2017 10 01.
Article
em En
| MEDLINE
| ID: mdl-29089420
ABSTRACT
Maternal imprinting at the Xist gene is essential to achieve paternal allele-specific imprinted X-chromosome inactivation (XCI) in female mammals. However, the mechanism underlying Xist imprinting is unclear. Here we show that the Xist locus is coated with a broad H3K27me3 domain that is established during oocyte growth and persists through preimplantation development in mice. Loss of maternal H3K27me3 induces maternal Xist expression and maternal XCI in preimplantation embryos. Our study thus identifies maternal H3K27me3 as the imprinting mark of Xist.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Histona-Lisina N-Metiltransferase
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Impressão Genômica
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Regulação da Expressão Gênica no Desenvolvimento
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Inativação do Cromossomo X
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RNA Longo não Codificante
Limite:
Animals
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article