Reaction Catalyzed by GenK, a Cobalamin-Dependent Radical S-Adenosyl-l-methionine Methyltransferase in the Biosynthetic Pathway of Gentamicin, Proceeds with Retention of Configuration.

Kim, Hak Joong; Liu, Yung-Nan; McCarty, Reid M; Liu, Hung-Wen

Kim, Hak Joong; Liu, Yung-Nan; McCarty, Reid M; Liu, Hung-Wen.

Afiliação

Kim HJ; Division of Chemical Biology and Medicinal Chemistry, College of Pharmacy, and Department of Chemistry, University of Texas at Austin , Austin, Texas 78712, United States.
Liu YN; Division of Chemical Biology and Medicinal Chemistry, College of Pharmacy, and Department of Chemistry, University of Texas at Austin , Austin, Texas 78712, United States.
McCarty RM; Division of Chemical Biology and Medicinal Chemistry, College of Pharmacy, and Department of Chemistry, University of Texas at Austin , Austin, Texas 78712, United States.
Liu HW; Division of Chemical Biology and Medicinal Chemistry, College of Pharmacy, and Department of Chemistry, University of Texas at Austin , Austin, Texas 78712, United States.

J Am Chem Soc ; 139(45): 16084-16087, 2017 11 15.

Article em En | MEDLINE | ID: mdl-29091410

Assuntos

Vias Biossintéticas; Gentamicinas/metabolismo; Metiltransferases/metabolismo; S-Adenosilmetionina/metabolismo; Vitamina B 12/metabolismo; Domínio Catalítico; Metilação; Metiltransferases/química; Especificidade por Substrato

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: S-Adenosilmetionina / Vitamina B 12 / Gentamicinas / Vias Biossintéticas / Metiltransferases Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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