Maternal sepsis in the era of genomic medicine.
Arch Gynecol Obstet
; 297(1): 49-60, 2018 01.
Article
em En
| MEDLINE
| ID: mdl-29103195
ABSTRACT
PURPOSE:
Maternal sepsis remains one of the leading causes of direct and indirect maternal mortality both in high- and low-income environments. In the last two decades, systems biology approaches, based on '-omics' technologies, have started revolutionizing the diagnosis and management of the septic syndrome. The scope of this narrative review is to present an overview of the basic '-omics' technologies, exemplified by cases relevant to maternal sepsis.METHODS:
Narrative review of the new '-omics' technologies based on a detailed review of the literature.RESULTS:
After presenting the main 'omics' technologies, we discuss their limitations and the need for integrated approaches that encompass research efforts across multiple '-omics' layers in the '-omics' cascade between the genome and the phenome.CONCLUSIONS:
Systems biology approaches are revolutionizing the research landscape in maternal sepsis. There is a need for increased awareness, from the side of health practitioners, as a requirement for the effective implementation of the new technologies in the research and clinical practice in maternal sepsis.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Complicações Infecciosas na Gravidez
/
Sepse
/
Genômica
/
Metabolômica
Tipo de estudo:
Etiology_studies
Limite:
Female
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Humans
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Pregnancy
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article